628320-79-6

Basic information

• Product Name: 2,3-bis(4-fluorophenyl)-1H-indole
• Synonyms: 2,3-bis(4-fluorophenyl)-1H-indole
• CAS NO: 628320-79-6
• Molecular Weight: 305.327
• Mol File: 628320-79-6.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 2,3-bis(4-fluorophenyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-bis(4-fluorophenyl)-1H-indole(628320-79-6)
• EPA Substance Registry System: 2,3-bis(4-fluorophenyl)-1H-indole(628320-79-6)

Safety Data

• Hazardous Substances Data: 628320-79-6(Hazardous Substances Data)

Upstream product

• 615-43-0 2-iodophenylamine 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 
• 52670-38-9 2-ethynylaniline 
• 352-34-1 4-fluoro-1-iodobenzene 
• 143360-93-4 N-(2-ethynylphenyl)-2,2,2-trifluoroacetamide 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 5216-31-9 1,2-bis(4-fluorophenyl)acetylene 
• 42116-43-8 tert-butyl 2-phenylhydrazine-1-carboxylate 
• 98-95-3 nitrobenzene 
• 52512-27-3 N-phenyl-C-mesitylnitrone 
• 59-88-1 phenylhydrazine hydrochloride 
• 62-53-3 aniline 
• 114-83-0 1-acetyl-2-phenylhydrazine 
• 459-57-4 4-fluorobenzaldehyde 

Relevant articles and documents

Sequential Sonogashira/intramolecular aminopalladation/cross-coupling ofortho-ethynyl-anilines catalyzed by a single palladium source: rapid access to 2,3-diarylindoles

We have developed a practical and efficient one-pot protocol for the synthesis of 2,3-diarylindolesviaPd-catalyzed bis-arylative cyclization of variouso-ethynylanilines with aryl iodides. Mechanism studies showed that a Pd-catalyzed Sonogashira reaction took place firstly, giving an internal alkyne intermediate, which subsequently underwent intramolecular aminopalladation/cross-coupling to give access to 2,3-diarylindoles. The present methodology exhibits a broad substrate scope, producing various 2,3-diaryl indoles bearing two different aryl groups.

Selective Synthesis of N-Unsubstituted and N-Arylindoles by the Reaction of Arynes with Azirines

The transition-metal-free and temperature-dependent highly selective reaction of arynes with 2H-azirines allowing the synthesis of either N-unsubstituted or N-arylindoles has been developed. At 60 °C, arynes generated from 2-(trimethylsilyl)aryl triflates smoothly insert into 2H-azirines to form 2,3-diarylindoles with high selectivity. Interestingly, when the reaction was performed at -10 °C, the selectivity was switched to the formation of 1,2,3-triarylindoles in good yields.

A kind of high-efficient synthetic indole and isoquinoline derivatives (by machine translation)

The invention discloses a substituted indole and isoquinoline preparation method, which belongs to the technical field of organic chemical synthesis. This method adopts the oxygen as the oxidizing agent, various substituents substituted alkyne starting material of the aromatic amine or [...] , by transition metal-catalyzed, get containing indole or isoquinoline compound of the structure. The reaction raw material, oxidizing agent and cheap and easily obtained catalyst, synthesis technique is simple, which greatly reduces the cost of synthesizing; mild reaction conditions, high yield, easy industrialization; reaction raw materials and catalyst cleaning non-toxic, small pollution to the environment. Such compounds and their derivatives as an important fine chemicals, in the medical, agricultural chemicals, perfume and widely used photoelectric and other industries. (by machine translation)