630424-79-2

Basic information

• Product Name: 4-FLUORO-3-METHOXYCINNAMIC ACID
• Synonyms: 4-FLUORO-3-METHOXYCINNAMIC ACID;RARECHEM BK HW 0080;Jrd-1623;3-Methoxy-4-fluorocinnamicacid;3-(4-Fluoro-3-methoxyphenyl)acrylic acid
• CAS NO: 630424-79-2
• Molecular Formula: C₁₀H₉FO₃
• Molecular Weight: 196.18
• Product Categories: Cinnamic acid;Acids & Esters;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Fluorine series
• Mol File: 630424-79-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 334℃
• Flash Point: 156℃
• Appearance: /
• Density: 1.280
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: 2-8°C
• PKA: 4.37±0.10(Predicted)
• CAS DataBase Reference: 4-FLUORO-3-METHOXYCINNAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-3-METHOXYCINNAMIC ACID(630424-79-2)
• EPA Substance Registry System: 4-FLUORO-3-METHOXYCINNAMIC ACID(630424-79-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 630424-79-2(Hazardous Substances Data)

Usage

General Description

4-Fluoro-3-methoxycinnamic acid is a chemical compound with the molecular formula C10H9FO3. It is a derivative of cinnamic acid, and it contains a fluorine atom and a methoxy group attached to the cinnamic acid structure. 4-Fluoro-3-methoxycinnamic acid is commonly used in organic synthesis and pharmaceutical research due to its potential biological activities. It has been studied for its potential antifungal and antimicrobial properties, as well as its use in the development of new drugs for various medical conditions. Additionally, 4-Fluoro-3-methoxycinnamic acid has been investigated for its potential as a building block in the synthesis of various organic molecules. Overall, this compound has shown promise in various research applications and continues to be of interest in the scientific community.

InChI:InChI=1/C10H9FO3/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6H,1H3,(H,12,13)/b5-3+

Upstream product

• 141-82-2 malonic acid 
• 128495-46-5 4-fluoro-3-methoxybenzaldehyde 
• 110-89-4 piperidine 

Downstream Products

• 864960-96-3 3-(4-fluoro-3-methoxyphenyl)propanoic acid 
• 1224104-16-8 C₁₄H₁₇FO₃ 
• 1224104-17-9 ethyl 3-(3,5-difluoro-4-hydroxyphenyl)-2-ethoxypropanoate 
• 1409964-67-5 (E)-3-(4-fluoro-3-methoxyphenyl) acryloyl azide 
• 630422-99-0 1-chloro-7-fluoro-6-methoxyisoquinoline 

Relevant articles and documents

Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate

The acetylcholinesterase (AChE) inhibitors remain key therapeutic drugs for the treatment of Alzheimer's disease (AD). However, the low-safety window limits their maximum therapeutic benefits. Here, a novel kinetics-driven drug design strategy was employed to discover new-generation AChE inhibitors that possess a longer drug-target residence time and exhibit a larger safety window. After detailed investigations, compound 12 was identified as a highly potent, highly selective, orally bioavailable, and brain preferentially distributed AChE inhibitor. Moreover, it significantly ameliorated cognitive impairments in different mouse models with a lower effective dose than donepezil. The X-ray structure of the cocrystal complex provided a precise binding mode between 12 and AChE. Besides, the data from the phase I trials demonstrated that 12 had good safety, tolerance, and pharmacokinetic profiles at all preset doses in healthy volunteers, providing a solid basis for its further investigation in phase II trials for the treatment of AD.

GPR120 RECEPTOR AGONISTS AND USES THEREOF

GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.

GPR120 RECEPTOR AGONISTS AND USES THEREOF

GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.