6308-53-8

Basic information

• Product Name: 3-phenyl-2-(quinoline-2-carbonylamino)propanoic acid
• Synonyms: 3-phenyl-2-(quinoline-2-carbonylamino)propanoic acid
• CAS NO: 6308-53-8
• Molecular Formula: C19H16N2O3
• Molecular Weight: 320.34
• Mol File: 6308-53-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 626°C at 760 mmHg
• Flash Point: 332.4°C
• Appearance: /
• Density: 1.303g/cm³
• Vapor Pressure: 1.56E-16mmHg at 25°C
• Refractive Index: 1.663
• CAS DataBase Reference: 3-phenyl-2-(quinoline-2-carbonylamino)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-2-(quinoline-2-carbonylamino)propanoic acid(6308-53-8)
• EPA Substance Registry System: 3-phenyl-2-(quinoline-2-carbonylamino)propanoic acid(6308-53-8)

Safety Data

• Hazardous Substances Data: 6308-53-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H16N2O3/c22-18(16-11-10-14-8-4-5-9-15(14)20-16)21-17(19(23)24)12-13-6-2-1-3-7-13/h1-11,17H,12H2,(H,21,22)(H,23,24)

Upstream product

• 50342-01-3 quinolin-2-ylcarbonyl chloride 
• 150-30-1 Phenylalanine 
• 93-10-7 quinoline-2-carboxylic acid 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 136465-99-1 2,5-dioxopyrrolidin-1-ylquinoline-2-carboxylate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 

Relevant articles and documents

A convenient and efficient synthesis of dipeptidyl benzoxaboroles and their peptidomimetics

We have developed a convenient and efficient method for the synthesis of dipeptidyl benzoxaboroles and their peptidomimetics. The novel dipeptidyl benzoxaboroles were obtained by the protecting-group-free coupling of 6-amino-1,3-dihydro-2,1-benzoxaborol-1-ol with various N-(arylcarbonyl) phenylalanines. Bioisosteric replacement of the terminal amide moiety of dipeptidyl benzoxaboroles by 1,3,4-oxadiazoles or 4H-3,1-benzothiazin-4-one provided their peptidomimetics with good molecular diversity. These transformations were based on the pluripotency of methyl (S)-2-isothiocyanato-3- phenylpropanoate and were highlighted by mild reaction conditions, high atom efficiency, and good to excellent isolated yields. This method is a valuable addition to the development of novel drug-like boronic acid molecules. Georg Thieme Verlag Stuttgart ? New York.

Solid-phase synthesis of unnatural amino acids using unactivated alkyl halides

Conditions were developed for the efficient alkylation of the resin-bound benzophenone imine of glycine with a variety of unreactive alkyl halides. Alkylations were accomplished at room temperature in NMP using the phosphazene-type base, BEMP.