63091-82-7

Basic information

• Product Name: BOC-D-THZ-OH
• Synonyms: BOC-D-THIOPRO-OH;BOC-D-THZ-OH;BOC-(S)-THIAZOLIDINE-4-CARBOXYLIC ACID;(S)-N-(TERT-BUTYLOXYCARBONYL)-THIAZOLIDINE-4-CARBOXYLIC ACID;N-ALPHA-T-BUTYLOXYCARBONYL-D-THIAZOLIDINE-4-CARBOXYLIC ACID;N-ALPHA-T-BUTOXYCARBONYL-D-THIAZOLIDINE-4-CARBOXYLIC ACID;N-ALPHA-T-BUTOXYCARBONYL-D-THIOPROLINE;N-tert-Butoxycarbonyl-D-hepalidine
• CAS NO: 63091-82-7
• Molecular Formula: C₉H₁₅NO₄S
• Molecular Weight: 233.28
• Product Categories: Amino Acids
• Mol File: 63091-82-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 385.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.305±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.53±0.20(Predicted)
• CAS DataBase Reference: BOC-D-THZ-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-D-THZ-OH(63091-82-7)
• EPA Substance Registry System: BOC-D-THZ-OH(63091-82-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 63091-82-7(Hazardous Substances Data)

Usage

General Description

BOC-D-THZ-OH is a chemical compound with the molecular formula C17H20N2O5S. It is a protected form of the amino acid thiazolidine-4-carboxylic acid, commonly used in peptide synthesis and pharmaceutical research. BOC-D-THZ-OH is a white solid that is soluble in dimethyl sulfoxide and methanol. It is commonly used in the production of pharmaceutical drugs and in biochemical research as a building block for the synthesis of peptide and protein-based compounds. BOC-D-THZ-OH is known for its role in the development of therapeutic agents and the study of peptide structure-activity relationships. It is important in the field of medicinal chemistry and drug discovery.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 34592-47-7 L-thioproline 
• 444-27-9 L-thiaproline 

Downstream Products

• 425403-78-7 (S)-4-[(S)-2-(2'-Methoxy-biphenyl-4-yl)-1-methoxycarbonyl-ethylcarbamoyl]-thiazolidine-3-carboxylic acid tert-butyl ester 
• 397867-84-4 methyl N-benzoyl-N-[piperidin-4-yl-N-(N-Boc-(S)-thiazolidine-4-carbonyl)]-(S)-methioninate 
• 739365-93-6 (4S)-3-(tert-Butyloxycarbonyl)thiazolidine-4-carboxamide 
• 104434-77-7 6-(4-(3-tert.-Butoxycarbonyl-L-thiazolidin-4-yl-carbonyl-amino)phenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone 
• 229328-24-9 C₂₆H₂₉Cl₂N₃O₆S 
• 1318780-42-5 C₂₂H₃₃N₃O₆S 
• 1318780-43-6 C₃₀H₃₉N₃O₈S 

Relevant articles and documents

BENZIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING BENZIDINE DERIVATIVE FOR TREATING LIVER DISEASE CAUSED BY HEPATITIS C VIRUS

The disclosed compounds have antiviral activity against C-type virus, an optical isomer thereof, a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating liver disease caused by hepatitis C virus. The benzidine derivative according to the present invention has excellent antiviral activity against hepatitis C virus and exhibits excellent medicinal activity in the living body, and thus the pharmaceutical composition containing the same as an active ingredient can be useful as a pharmaceutical composition for preventing or treating liver disease, such as acute hepatitis C, chronic hepatitis C, cirrhosis, or hepatocellular carcinoma, caused by C-type virus.

NEW ADAMANTANE DERIVATIVES AS DIPEPTIDYL, PEPTIDASE IV INHIBITORS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention relates to dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula (A): wherein R1, R2, Y, and n are as defined herein, pharmaceutical compositions containing the same, processes for their preparation, and methods for treating disorders mediated by DPP-IV inhibition, such as diabetes, especially Type II diabetes, with them.

NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS; PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS THEREOF

The present invention relates to novel dipeptidyl peptidase IV (DPP-IV) inhibitors or general formula (1) useful for treating diabetes, non-insulin dependent diabetes mellitus, impaired glucose tolerance, inflammatory bowel disease, ulcerative colitis,Chron’s disease, obesity, and metabolic syndrome.