6312-82-9

Basic information

• Product Name: 3-ETHOXY-4-HYDROXY-5-IODOBENZALDEHYDE
• Synonyms: CHEMBRDG-BB 6046815;3-ETHOXY-4-HYDROXY-5-IODOBENZALDEHYDE;AKOS B004214;ART-CHEM-BB B004214;VITAS-BB TBB005612;3-ethoxy-4-hydroxy-5-iodobenzaldehyde(SALTDATA: FREE);NSC40555;Oprea1_246589
• CAS NO: 6312-82-9
• Molecular Formula: C₉H₉IO₃
• Molecular Weight: 292.07
• Mol File: 6312-82-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 318 °C at 760mmHg
• Flash Point: 146.1 °C
• Appearance: /
• Density: 1.801 g/cm³
• Vapor Pressure: 0.000199mmHg at 25°C
• Refractive Index: 1.649
• CAS DataBase Reference: 3-ETHOXY-4-HYDROXY-5-IODOBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ETHOXY-4-HYDROXY-5-IODOBENZALDEHYDE(6312-82-9)
• EPA Substance Registry System: 3-ETHOXY-4-HYDROXY-5-IODOBENZALDEHYDE(6312-82-9)

Safety Data

• Hazardous Substances Data: 6312-82-9(Hazardous Substances Data)

Usage

General Description

3-ETHOXY-4-HYDROXY-5-IODOBENZALDEHYDE is a chemical compound with the molecular formula C9H9IO3. It is a yellow crystalline powder that is used in organic synthesis and pharmaceutical research. 3-ETHOXY-4-HYDROXY-5-IODOBENZALDEHYDE is known for its diverse applications, including its use as a chemical intermediate in the production of various drugs and other organic compounds. It is also used in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, 3-ETHOXY-4-HYDROXY-5-IODOBENZALDEHYDE has potential industrial applications in the production of various specialty chemicals.

InChI:InChI=1/C9H9IO3/c1-2-13-8-4-6(5-11)3-7(10)9(8)12/h3-5,12H,2H2,1H3

Upstream product

• 121-32-4 4-hydroxy-3-ethoxybenzaldehyde 

Downstream Products

• 225939-36-6 8-Ethoxy-2,2-dimethyl-2H-chromene-6-carbaldehyde 
• 1357165-42-4 4-amino-3-[6-(2-butoxy-3-ethoxy-5-formylphenyl)pyridin-3-ylazo]naphthalene-1-sulfonic acid sodium salt 
• 1357166-87-0 2-butoxy-1-ethoxy-5-(diethoxymethyl)-3-iodobenzene 
• 1357166-88-1 2-butoxy-3-ethoxy-5-formylphenylboronic acid 
• 1357166-89-2 4-butoxy-3-ethoxy-5-(5-nitropyridin-2-yl)benzaldehyde 
• 1357166-90-5 3-(5-aminopyridin-2-yl)-4-butoxy-5-ethoxybenzaldehyde 
• 832673-72-0 4-butoxy-3-ethoxy-5-iodobenzaldehyde 

Relevant articles and documents

Efficient and sustainable laccase-catalyzed iodination of: P -substituted phenols using KI as iodine source and aerial O2 as oxidant

The laccase-catalyzed iodination of p-hydroxyarylcarbonyl- and p-hydroxyarylcarboxylic acid derivatives using KI as iodine source and aerial oxygen as the oxidant delivers the corresponding iodophenols in a highly efficient and sustainable manner with yields up to 93% on a preparative scale under mild reaction conditions.

Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitors

The development of inhibitors blocking STAT3 transcriptional activity is a promising therapeutic approach against cancer and inflammatory diseases. In this context, the selectivity of inhibitors against the STAT1 transcription factor is crucial as STAT3 and STAT1 play opposite roles in the apoptosis of tumor cells and polarization of the immune response. A structure-based virtual screening followed by a luciferase-containing promoter assay on STAT3 and STAT1 signaling were used to identify a selective STAT3 inhibitor. An important role of the aminotetrazole group in modulating STAT3 and STAT1 inhibitory activities has been established. Optimization of the hit compound leads to 23. This compound inhibits growth and survival of cells with STAT3 signaling pathway while displaying a minimal effect on STAT1 signaling. Moreover, it prevents lymphocyte T polarization into Th17 and Treg without affecting their differentiation into Th1 lymphocyte.

NAPHTHALENE DERIVATIVE

The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I) (R is as defined in the description) or oxides, esters, prodrugs, pharmaceutically acceptable salts or solvates thereof. The compounds can regulate VCP activity, and thus are useful for treating VCP-mediated diseases such as neurodegenerative diseases.