6317-27-7

Basic information

• Product Name: 4-chlorophenyl methanesulfonate
• Synonyms: 4-Chlorophenyl methanesulfonate; methanesulfonic acid, 4-chlorophenyl ester
• CAS NO: 6317-27-7
• Molecular Formula: C₇H₇ClO₃S
• Molecular Weight: 206.6467
• Mol File: 6317-27-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 323°C at 760 mmHg
• Flash Point: 149.1°C
• Density: 1.411g/cm³
• Vapor Pressure: 0.000508mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: 4-chlorophenyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chlorophenyl methanesulfonate(6317-27-7)
• EPA Substance Registry System: 4-chlorophenyl methanesulfonate(6317-27-7)

Safety Data

• Hazardous Substances Data: 6317-27-7(Hazardous Substances Data)

Usage

Description

4-Chlorophenyl methanesulfonate is an organosulfur compound with the chemical formula C7H7ClO3S. It features a sulfonate ester group and a chlorophenyl group, making it a versatile reagent in organic chemistry. This colorless to light yellow liquid possesses a slightly sweet odor and is soluble in organic solvents like ether and chloroform.

Uses

Used in Organic Synthesis:
4-Chlorophenyl methanesulfonate serves as a reagent for converting alcohols into their corresponding mesylates, which are valuable intermediates in a variety of chemical processes. Its ability to facilitate these conversions makes it an important compound in advancing organic synthesis techniques.
Used in Chemical Reactions:
As a versatile reagent, 4-chlorophenyl methanesulfonate is utilized in multiple chemical reactions across different industries. Its unique structure allows it to participate in a range of processes, contributing to the development and production of various chemical products.

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 106-48-9 4-chloro-phenol 
• 64128-19-4 (CH₃)3SnO(C₆H₄)Cl 
• 102-69-2 tri-n-propylamine 
• 103-83-3 N,N'-dimethylbenzylamine 
• 102-82-9 tributyl-amine 
• 616-39-7 N,N-diethylnmethylamine 
• 111-74-0 N,N'-diethylethylenediamine 
• 98-94-2 N,N-dimethyl-cyclohexanamine 
• 772-54-3 N,N-diethylbenzylamine 
• 620-40-6 tribenzylamine 
• 121-44-8 triethylamine 
• 17067-40-2 4-(methylthio)phenyl methanesulfonate 
• 75-75-2 methanesulfonic acid 

Downstream Products

• 106-48-9 4-chloro-phenol 
• 138373-13-4 Methanesulfonyl-methanesulfonic acid 4-chloro-phenyl ester 
• 17241-10-0 tris(p-tolylthio)methane 
• 138373-09-8 p-Tolylsulfanyl-methanesulfonic acid 4-chloro-phenyl ester 
• 27064-08-0 S-p-tolyl methanethioate 
• 39145-47-6 1-(4-chlorophenoxy)-2-nitrobenzene 
• 146537-85-1 2-(4-chlorophenoxy)-benzonitrile 
• 1836-74-4 4-(4-chlorophenoxy)nitrobenzene 
• 98274-02-3 p-chlorophenyl chloromethanesulfonate 
• 6966-45-6 4-chlorobenzylsulfonyl chloride 
• 1070731-18-8 4-(N-methyl-N-phenylamino)phenyl methanesulfonate 
• 92-94-4 [1,1';4',1'']terphenyl 
• 129236-45-9 [1,1′-biphenyl]-4-yl methanesulfonate 
• 24573-38-4 4-chlorophenolate 

Relevant articles and documents

Chromatography-Free and Eco-Friendly Synthesis of Aryl Tosylates and Mesylates

Two chromatography-free and eco-friendly protocols have been developed to synthesize aryl tosylates and mesylates by the tosylation and mesylation of the corresponding hydroxyarenes, respectively. These protocols are superior to other known ones regarding

Pitfalls in assessing the α-effect: Reactions of substituted phenyl methanesulfonates with HOO-, OH-, and substituted phenoxides in H2O

Toward resolving the current controversy regarding the validity of the α-effect, we have examined the reactions of Y-substituted phenyl methanesulfonates 1a-1l with HOO-, OH-, and Z-substituted phenoxides in the gas phase versus solu

A simple preparation of aryl methanesulfonates by thermal decomposition of dry arenediazonium O-benzenedisulfonimides in methanesulfonic acid

Aryl methansulfonates 3 (18 examples) were easily prepared by thermal decomposition of dry arenediazonium o-benzenedisulfonimides 1 in methanesulfonic acid (2). The reactions were carried out at temperatures between 60 and 120°C for times between 0.5 and 8 h. The aryl methanesulfonates were obtained in reproducible yield of 70-90%, with few exceptions. In all cases the o-benzenedisulfonimide (4) could be recovered in good yields which can then be reused to prepare the salts 1. When thermal decomposition of salts 1 was carried out in trifluoromethanesulfonic acid (5) at 90-120°C for 1-2 h, aryl trifluoromethanesulfonates 6 were obtained in 73-78% yield (3 examples).