6323-99-5 Usage
Description
2-amino-4-phosphonobutyric acid, also known as DL-AP4, is a broad-spectrum glutamatergic antagonist with neuroprotective properties. It is a synthetic amino acid that selectively inhibits the activation of metabotropic glutamate receptors, playing a crucial role in modulating synaptic transmission and neuronal excitability.
Uses
Used in Pharmaceutical Industry:
2-amino-4-phosphonobutyric acid is used as a neuroprotective agent for the treatment of neurological disorders such as cerebral ischemia, epilepsy, and neurodegenerative diseases. Its ability to inhibit the activation of metabotropic glutamate receptors helps in reducing excitotoxicity, oxidative stress, and inflammation, thereby providing neuroprotection.
Used in Research Applications:
2-amino-4-phosphonobutyric acid is used as a research tool in neuroscience to study the role of glutamate receptors in synaptic transmission, neuronal excitability, and plasticity. It helps researchers understand the underlying mechanisms of various neurological disorders and develop potential therapeutic strategies.
Used in Drug Development:
2-amino-4-phosphonobutyric acid is used as a lead compound in the development of new drugs targeting metabotropic glutamate receptors for the treatment of neurological and psychiatric disorders. Its selective inhibition of these receptors offers a promising approach for the management of conditions such as Alzheimer's disease, Parkinson's disease, and schizophrenia.
Check Digit Verification of cas no
The CAS Registry Mumber 6323-99-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,2 and 3 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6323-99:
(6*6)+(5*3)+(4*2)+(3*3)+(2*9)+(1*9)=95
95 % 10 = 5
So 6323-99-5 is a valid CAS Registry Number.
6323-99-5Relevant articles and documents
Synthesis and characterization of intermediate and transition-state analogue inhibitors of γ-gutamyl peptide ligases
Inoue, Makoto,Hiratake, Jun,Sakata, Kanzo
, p. 2248 - 2251 (2007/10/03)
The phosphonodifluoromethyl ketone and phosphonofluoridate derivatives of L-glutamic acid were synthesized and characterized as analogues of the γ-glutamyl phosphate intermediate and the tetrahedral transition state, respectively, for the inhibition of γ-
PREPARATION D'ACIDES AMINOCARBOXY-ALKYLPHOSPHONIQUES OPTIQUEMENT ACTIFS
Villanueva, J. M.,Collignon, N.,Guy, A.,Savignac, Ph.
, p. 1299 - 1306 (2007/10/02)
In aqueous solution ω-formylalkylphosphonates in the presence of hydrogen cyanide and (S) (-) α-methylbenzylamine give optically active aminonitriles with an enantiomeric excess of 50percent.Phosphonic aminonitriles are submitted to acid hydrolysis, then esterified and debenzylated without any epimerization.The separation is performed either with the acid or with the ester.All the operations are monitored by NMR (1H, 13C, 31P) and whenever possible, by GC.
