63237-84-3Relevant articles and documents
Divergent and Regioselective Synthesis of Pyrazolo[1,5- a]pyridines and Imidazo[1,5- a]pyridines
Mennie, Katrina M.,Reutershan, Michael H.,White, Catherine,Adams, Bruce,Becker, Bridget,Deng, James,Katz, Jason D.,Lablue, Elisabeth,Margrey, Kaila,Saurí, Josep
, p. 4694 - 4698 (2021/06/28)
Nitrogenous heterocycles are ubiquitous in pharmaceuticals and drug-like compounds; however, regioselective synthesis has proved challenging. Herein we report our efforts to develop a regioselective method for the synthesis of pyrazolo[1,5-a]pyridines and the serendipitous discovery of a protocol for the regioselective formation of imidazo[1,5-a]pyridines. Together, these transformations allow for the rapid and selective formation of two important heterocyclic motifs from a common intermediate.
Unexpected cleavage of the Cpy-Cpybond in the reaction of 2,2′-bipyridine N,N′-diimines with acetylenes
Supranovich, Vyacheslav I.,Borodkin, Gennady I.,Vorob'Ev, Aleksey Yu.,Shubin, Vyacheslav G.
supporting information, p. 5377 - 5380 (2015/02/02)
An unusual cleavage of the Cpy-Cpybond in the reaction of 2,2′-bipyridine N,N′-diimine and its C-methyl substituted derivatives with acetylenes is described. The effect of the solvent on the yield of 7,7′-bipyrazolo[1,5-a]pyridine-2,2′,3,3′-tetracarboxylates and the products of cleavage of the Cpy-Cpybond has been studied. The mechanism of the cleavage reaction is discussed on the basis of DFT calculations.