63243-75-4

Basic information

• Product Name: 2-AMINO-5-CHLORO-BENZOIC ACID ETHYL ESTER
• Synonyms: RARECHEM AL BI 1516;2-AMINO-5-CHLORO-BENZOIC ACID ETHYL ESTER;ETHYL 2-AMINO-5-CHLOROBENZOATE;Benzoic acid, 2-aMino-5-chloro-, ethyl ester;XWWBMLMEVRIPSX-UHFFFAOYSA-N
• CAS NO: 63243-75-4
• Molecular Formula: C₉H₁₀ClNO₂
• Molecular Weight: 199.63
• Product Categories: Acids & Esters;Anilines, Amides & Amines;Chlorine Compounds
• Mol File: 63243-75-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 307.6 °C at 760 mmHg
• Flash Point: 139.8 °C
• Appearance: /
• Density: 1.262 g/cm³
• Vapor Pressure: 0.000717mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 2-AMINO-5-CHLORO-BENZOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-CHLORO-BENZOIC ACID ETHYL ESTER(63243-75-4)
• EPA Substance Registry System: 2-AMINO-5-CHLORO-BENZOIC ACID ETHYL ESTER(63243-75-4)

Safety Data

• Hazardous Substances Data: 63243-75-4(Hazardous Substances Data)

Usage

Uses

Ethyl 2-Amino-5-chlorobenzoate has been used as a reactant for the preparation of 10-methoxypyrazino[1,2-a]indole derivatives to be used as 5HT2C receptor ligands.

InChI:InChI=1/C9H10ClNO2/c1-2-13-9(12)7-5-6(10)3-4-8(7)11/h3-5H,2,11H2,1H3

Upstream product

• 64-17-5 ethanol 
• 635-21-2 5-chloroanthranilic acid 
• 87-25-2 2-ethoxycarbonylaniline 
• 51282-56-5 ethyl-5-chloro-2-nitrobenzoate 

Downstream Products

• 90870-00-1 Aethyl-2-methansulfonamido-5-chlorbenzoat 
• 885056-95-1 ethyl 5-chloro-2-(pyrrol-1-yl)benzoate 
• 885056-97-3 5-chloro-2-(1H-pyrrol-1-yl)benzaldehyde 
• 885056-96-2 5-chloro-2-(pyrrol-1-yl)benzyl alcohol 
• 941306-24-7 (6-chloro-3a-aza-cyclopenta[a]inden-8-ylidene)-phenyl-amine 
• 90208-60-9 3-benzoyl-6-chloro-4-hydroxy-2-quinolone 
• 90182-41-5 ethyl 2-benzoylacetylamino-5-chlorobenzoate 
• 1352126-78-3 2-[2-(2-fluorobenzoylamino)benzoylamino]-5-chlorobenzoic acid 
• 59187-55-2 N-(4-chloro-2-methoxycarbonylphenyl)-(2-amino)phenylcarboxamide 
• 1542549-21-2 ethyl 5-chloro-2-[(2,6-dichloro-5-nitropyrimidin-4-yl)amino]benzoate 

Relevant articles and documents

2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS

The present invention relates to Nav1.8 Inhibitor 2,3-dihydroquinazolin compounds of Formula (X); wherein Y', X', B', R1', R2', R3', R5', R6', R7', and z1 are as defined herein; or pharmaceutically acceptable salts or tautomer forms thereof, corresponding pharmaceutical compositions or formulations, methods or processes of compound preparation, methods, compounds for use in, uses for and/or combination therapies for treating pain and/or pain-related or associated disease(s), disorder(s) or condition(s), respectively.

Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives

Smoothened (Smo) is the signal transducer of the Hedgehog (Hh) pathway and its stimulation is considered a potential powerful tool in regenerative medicine to treat severe tissue injuries. Starting from GSA-10, a recently reported Hh activator acting on Smo, we have designed and synthesized a new class of quinolone-based compounds. Modification and decoration of three different portions of the original scaffold led to compounds able to induce differentiation of multipotent mesenchymal cells into osteoblasts. The submicromolar activity of several of these new quinolones (0.4–0.9?μM) is comparable to or better than that of SAG and purmorphamine, two reference Smo agonists. Structure-activity relationships allow identification of several molecular determinants important for the activity of these compounds.

NEW ANTIVIRAL COMPOUNDS

The present invention provides new antiviral compounds and pharmacological compositions comprising these new compounds and their use in the prophylaxis, prevention and treatment of viral infections, particularly adenovirus and herpes virus infections.