63250-32-8

Basic information

• Product Name: SUC-PRO-OH
• Synonyms: N-ALPHA-SUCCINYL-L-PROLINE;N-SUCCINYL-L-PROLINE;succinylproline;Succinyl-L-proline≥ 99% (TLC);Suc-L-Pro-OH;SUCCINYL-L-PROLINE;SUC-PROLINE;SUC-PRO-OH
• CAS NO: 63250-32-8
• Molecular Formula: C9H13NO5
• Molecular Weight: 215.2
• Product Categories: A to;Angiotensin Converting Enzyme;Angiotensin Converting EnzymeEnzyme Inhibitors by Enzyme;Angiotensin Converting EnzymePeptides for Cell Biology;Enzyme Inhibitors;Protease Inhibitor Specificity Index;Protease Inhibitors
• Mol File: 63250-32-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 519.5°C at 760 mmHg
• Flash Point: 268°C
• Appearance: /
• Density: 1.425g/cm³
• Vapor Pressure: 3.46E-12mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: −20°C
• PKA: 3.53±0.20(Predicted)
• CAS DataBase Reference: SUC-PRO-OH(CAS DataBase Reference)
• NIST Chemistry Reference: SUC-PRO-OH(63250-32-8)
• EPA Substance Registry System: SUC-PRO-OH(63250-32-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 63250-32-8(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

InChI:InChI=1/C9H13NO5/c11-7(3-4-8(12)13)10-5-1-2-6(10)9(14)15/h6H,1-5H2,(H,12,13)(H,14,15)/t6-/m0/s1

Upstream product

• 108-30-5 succinic acid anhydride 
• 147-85-3 L-proline 

Relevant articles and documents

Captopril analogues as metallo-β-lactamase inhibitors

A number of captopril analogues were synthesised and tested as inhibitors of the metallo-β-lactamase IMP-1. Structure–activity studies showed that the methyl group was unimportant for activity, and that the potencies of these inhibitors could be best improved by shortening the length of the mercaptoalkanoyl side-chain. Replacing the thiol group with a carboxylic acid led to complete loss of activity, and extending the length of the carboxylate group led to decreased potency. Good activity could be maintained by substituting the proline ring with pipecolic acid.

CARBOXYACYLPROLINE DERIVATIVES

New carboxyalkylacylamino acids which are derivatives of proline, pipecolic acid and azetidine-2-carboxylic acid and have the general formula STR1 are useful as angiotensin converting enzyme inhibitors.