63254-88-6

Basic information

• Product Name: 2-{[(benzyloxy)carbonyl]amino}benzoic acid
• CAS NO: 63254-88-6
• Molecular Formula: C₁₅H₁₃NO₄
• Molecular Weight: 271.268
• Mol File: 63254-88-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 417°C at 760 mmHg
• Flash Point: 206°C
• Density: 1.342g/cm³
• Vapor Pressure: 1.06E-07mmHg at 25°C
• Refractive Index: 1.649
• CAS DataBase Reference: 2-{[(benzyloxy)carbonyl]amino}benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[(benzyloxy)carbonyl]amino}benzoic acid(63254-88-6)
• EPA Substance Registry System: 2-{[(benzyloxy)carbonyl]amino}benzoic acid(63254-88-6)

Safety Data

• Hazardous Substances Data: 63254-88-6(Hazardous Substances Data)

Usage

Molecular Weight

257.26 g/mol

Structure

A benzene ring with a carboxyl group (-COOH) attached to the 2-position, an amino group (-NH2) attached to the same position as the carboxyl group, and a benzyloxy carbonyl group (-O-CH2-C6H5) attached to the amino group.

+ Appearance

White crystalline solid

+ Solubility

Slightly soluble in water, soluble in organic solvents like ethanol and methanol

+ Melting Point

165-170°C

+ Boiling Point

Not applicable, as it is a solid

Uses

+ As a protecting group in peptide synthesis
+ In pharmaceutical research and drug development
+ As a building block in the synthesis of complex organic molecules

Derivative of

Benzoic acid

Contains

+ A benzyloxy carbonyl group
+ An amino group attached to the benzene ring

Unique

Its chemical structure and properties make it an important building block in the synthesis of various complex organic molecules.

Upstream product

• 118-92-3 anthranilic acid 
• 501-53-1 benzyl chloroformate 
• 107717-51-1 2-(benzyloxy)-4H-3,1-benzoxazin-4-one 
• 31162-13-7 2-azidobenzoic acid 
• 1174302-46-5 2-benzyloxycarbonyl-1-[N-(benzyloxycarbonyl)]aniline 

Downstream Products

• 118-48-9 isatoic anhydride 
• 55301-30-9 Benzyloxycarbonylanthraniloylglycinethylester 
• 55301-32-1 Benzyloxycarbonylanthraniloylalaninethylester 
• 55376-07-3 Benzyloxycarbonylanthraniloyl-L-leucinethylester 
• 107717-51-1 2-(benzyloxy)-4H-3,1-benzoxazin-4-one 
• 192046-53-0 {2-[1-Methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-phenyl}-carbamic acid benzyl ester 
• 660438-75-5 [2-((4aR,6R,7R,8R,8aS)-8-Hydroxy-6-methoxy-2,2-dimethyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylcarbamoyl)-phenyl]-carbamic acid benzyl ester 
• 866431-44-9 benzyl (2-{[(1-{[(methyl)(phenyl)amino]carbonyl}cyclopentyl)amino]carbonyl}phenyl)carbamate 
• 866431-56-3 benzyl [2-({[2-(dimethylamino)-1-methyl-2-oxo-1-(phenylmethyl)ethyl]amino}carbonyl)phenyl]carbamate 
• 62581-74-2 N-hydroxysuccinimidyl 2-carbobenzyloxyaminobenzoate 
• 873556-40-2 5'-O-(N-(2-carbobenzyloxyaminobenzoyl)sulfamoyl)-2',3'-O-isopropylideneadenosine 
• 866431-45-0 1-[(2-{[(benzyloxy)carbonyl]amino}benzoyl)amino]cyclopentane-1-carboxylic acid 
• 866431-51-8 2-amino-N-{2-[(1-{[(methyl)(phenyl)amino]carbonyl}cyclopentyl)amino]-2-oxoethyl}benzamide 
• 866431-57-4 2-[(2-{[(benzyloxy)carbonyl]amino}benzoyl)amino]-2-methyl-3-phenylpropanoic acid 

Relevant articles and documents

Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation

Abstract: LSD1 is a lysine demethylase highly involved in initiation and development of cancer. To design highly effective covalent inhibitors, a strategy is to fill its large catalytic cleft by designing tranylcypromine (TCP) analogs decorated with long,

One-pot efficient synthesis of N α-urethane-protected β- And γ-amino acids

1-[(4-Methylphenyl)oxy]pyrrolidine-2,5-dione and 1-[(4-methylphenyl)oxy] piperidine-2,6-dione react in a Lossen-type reaction with primary alcohols in the presence of triethylamine to furnish corresponding N α- urethane-protected β-alanine and γ-aminopropionic acid (GABA), respectively, with excellent yields and purities, in an essentially "one-pot" procedure.

Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2,4-quinazolindiones

A series of 3-aryl-2,4-quinazolinediones with various substitution on aromatic rings has been prepared by solid-phase synthesis. Several compounds showed cytotoxicity on human colon carcinoma (Col2) tested by SRB method.