63296-46-8 Usage
Description
URSODEOXYCHOLIC ACID-24-13C is a labeled compound derived from Ursodeoxycholic Acid (U850000), which is a naturally occurring bile acid. It is characterized by the presence of a 13C isotope at the 24th carbon position, making it distinguishable from its non-labeled counterpart. This labeled version is utilized in various applications due to its unique properties and ability to be tracked in biological systems.
Uses
Used in Pharmaceutical Industry:
URSODEOXYCHOLIC ACID-24-13C is used as an anticholelithogenic agent for the treatment and prevention of cholesterol gallstones. Its application is based on its ability to dissolve cholesterol stones and reduce the risk of their recurrence.
Used in Research and Development:
In the field of research, URSODEOXYCHOLIC ACID-24-13C serves as a valuable tool for studying bile acid metabolism, transport, and their role in various physiological and pathological processes. The labeled compound allows for easier tracking and quantification of its distribution and metabolism within the body.
Used in Diagnostic Applications:
URSODEOXYCHOLIC ACID-24-13C is employed in diagnostic procedures to assess bile acid absorption, secretion, and metabolism. The labeled compound can be used to identify and monitor various liver and gallbladder disorders, as well as to evaluate the effectiveness of treatments for these conditions.
Used in Drug Development:
The labeled compound can be utilized in the development of new drugs targeting bile acid metabolism and related pathways. By understanding the behavior of URSODEOXYCHOLIC ACID-24-13C in the body, researchers can design more effective and targeted therapies for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 63296-46-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,2,9 and 6 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 63296-46:
(7*6)+(6*3)+(5*2)+(4*9)+(3*6)+(2*4)+(1*6)=138
138 % 10 = 8
So 63296-46-8 is a valid CAS Registry Number.
63296-46-8Relevant articles and documents
An improved synthesis of 24 13C labeled bile acids using formyl esters and a modified lead tetraacetate procedure
Tserng,Klein
, p. 400 - 403 (2007/10/13)
An improved synthesis of 24 14C labeled bile acids has been achieved using formyl derivatives of bile acids and a modified lead tetraacetate procedure. The formylated bile acids were degraded by lead tetraacetate and lithium chloride to formylated 23 chloronorcholanes in 72 to 83% yield. Formylated 23-chloronorcholanes were converted to nitriles in dimethylformamide, which were then hydrolyzed to obtain C-24 labeled bile acids in yield of 80 to 90% of labeled sodium cyanide used. This method results in a higher yield and a purer product with less manipulation than previously reported procedures for synthesis of labeled bile acids.
