63321-79-9

Basic information

• Product Name: {2-[(dimethylamino)methyl]phenyl}methanol
• Synonyms: {2-[(dimethylamino)methyl]phenyl}methanol
• CAS NO: 63321-79-9
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.2322
• Mol File: 63321-79-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 244.9°Cat760mmHg
• Flash Point: 82.1°C
• Appearance: /
• Density: 1.033g/cm³
• Vapor Pressure: 0.0158mmHg at 25°C
• Refractive Index: 1.545
• CAS DataBase Reference: {2-[(dimethylamino)methyl]phenyl}methanol(CAS DataBase Reference)
• NIST Chemistry Reference: {2-[(dimethylamino)methyl]phenyl}methanol(63321-79-9)
• EPA Substance Registry System: {2-[(dimethylamino)methyl]phenyl}methanol(63321-79-9)

Safety Data

• Hazardous Substances Data: 63321-79-9(Hazardous Substances Data)

Usage

Description

2-[(dimethylamino)methyl]phenylmethanol is a chemical compound with the molecular formula C10H15NO. It is a secondary amine that contains a phenyl group attached to a methanol molecule through a dimethylaminoethyl linker. 2-[(dimethylamino)methyl]phenylmethanol is known for its versatile applications in organic chemistry and medicinal research.

Uses

Used in Organic Synthesis:
2-[(dimethylamino)methyl]phenylmethanol is used as a reagent in organic synthesis for [application reason] its ability to facilitate various chemical reactions and form new compounds.
Used in Pharmaceutical and Agrochemical Synthesis:
2-[(dimethylamino)methyl]phenylmethanol is used as a building block for the synthesis of various pharmaceuticals and agrochemicals for [application reason] its structural properties that allow for the creation of a wide range of bioactive molecules.
Used in Polymer Material Synthesis:
2-[(dimethylamino)methyl]phenylmethanol is used as a stabilizer in the synthesis of polymer materials for [application reason] its capacity to enhance the stability and performance of the resulting polymers.
Used in Medicinal Research:
2-[(dimethylamino)methyl]phenylmethanol has been studied for its potential pharmacological properties, including as an anti-cancer and anti-inflammatory agent for [application reason] its unique chemical structure that may contribute to therapeutic effects in various medical conditions.

InChI:InChI=1/C10H15NO/c1-11(2)7-9-5-3-4-6-10(9)8-12/h3-6,12H,7-8H2,1-2H3

Upstream product

• 55741-01-0 o-N,N-dimethylaminomethylbenzoic acid 
• 28276-79-1 ethyl 2-((dimethylamino)methyl)benzoate 
• 63321-82-4 o-(N,N-dimethylaminomethyl)benzyl acetate 
• 20320-37-0 2-(dimethylaminocarbonyl)benzoic acid 

Downstream Products

• 69384-26-5 2-(2-Dimethylaminomethyl-benzylsulfanyl)-ethylamine 
• 63321-82-4 o-(N,N-dimethylaminomethyl)benzyl acetate 
• 14609-74-6 p-nitrophenolate 
• 4385-35-7 isochroman-3-one 
• 67519-22-6 α-hydroxy-α'-cyano-o-xylene 
• 98988-24-0 (S)-2-Benzyloxy-3-methoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline 
• 98988-23-9 (+/-)-O-benzylisobharatamine 
• 98988-21-7 N-<2-(3-benzyloxy-4-methoxyphenyl)-ethyl>-(2-hydroxymethyl)phenylacetamide 
• 98988-20-6 N-<2-(4-benzyloxy-3-methoxyphenyl)-ethyl>-(2-hydroxymethyl)phenylacetamide 
• 145832-36-6 2-acetoxymethyl-N,N,N-trimethylbenzenemethanaminium iodide 
• 69384-55-0 1-[2-(2-Dimethylaminomethyl-benzylsulfanyl)-ethyl]-3-methyl-thiourea 

Relevant articles and documents

Internal amine-assisted attack of alcoholic hydroxy group on esters: Serine esterase models

o-(N,N-Dimethylaminomethyl)benzyl alcohol (o-DBA) shows extensive internal hydrogen bonding in aqueous solvent as evidenced by the following observations: (i) The ionization constant of protonated o-DBA is more than two times larger than that of protonated o-(N,N-dimethylaminomethyl)benzyl methyl ether (o-DBMEH+), (ii) The second-order rate constant for the cleavage of p-nitrophenyl acetate (PNPA) catalysed by o-DBA is more than 150 times larger than that catalysed by o-DBME.Similar observations are obtained in the cleavage of phenyl acetate (PA) also.The estimated contributions to the catalytic cleavage of PNPA and PA by the internally hydrogen bonded form of o-DBA are ca. 45 and 48 times, respectively, larger than the respective contributions by nonhydrogen bonded zwitterionic form of o-DBA.The deuterium oxide solvent isotope effect on the reactivity of o-DBA toward PNPA reveals that proton transfer is not important in the rate-determining step.The expulsion of leaving group (ArO-) from the zwitterionic tetrahedral addition intermediate formed due to the attack of nucleophile at ester carbonyl group is considered to be the rate-determining step.Both the pK and rate studies on the reactions of a few other amino alcohols and their methyl esters with PNPA do not show the presence of internal hydrogen bonding in these amino alcohols.Second-order rate constants for the reactions of PNPA with six tertiary amines of comparable structural features reveal a Bronsted plot of slope (βnuc) of 0.70 +/- 0.26.

Pyridyl-substituted imidazoles, compositions containing same and methods of use thereof

Novel imidazole of the formula: STR1 wherein Ring A is pyridyl group or a substituted pyridyl group; Ring B is phenyl group or a substituted phenyl group; R1 and R2 are hydrogen atom or are combined together to form a group of the formula: --(CH2)q --; m is 1 or 2; n is 0, 1 or 2; and q is 3 or 4, or a salt thereof are disclosed. Said derivative (I) and a salt thereof are useful as anti-ulcer agents.