63368-37-6

Basic information

• Product Name: (3-METHYLBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE
• Synonyms: [(3-METHYLPHENYL)METHYL]-TRIPHENYLPHOSPHONIUM CHLORIDE;(3-METHYLBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE;(3-Methylbenzyl)triphenylphosphonium chloride, 98 %;3-Methylbenzyltriphenylphosphonium chloride,99%
• CAS NO: 63368-37-6
• Molecular Formula: C₂₆H₂₄P*Cl
• Molecular Weight: 402.9
• Mol File: 63368-37-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: >300℃
• Appearance: /
• BRN: 4071111
• CAS DataBase Reference: (3-METHYLBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (3-METHYLBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE(63368-37-6)
• EPA Substance Registry System: (3-METHYLBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE(63368-37-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• Hazardous Substances Data: 63368-37-6(Hazardous Substances Data)

Usage

Chemical Properties

WHITE CRYSTALLINE POWDER

InChI:InChI=1/C26H24P.ClH/c1-22-12-11-13-23(20-22)21-27(24-14-5-2-6-15-24,25-16-7-3-8-17-25)26-18-9-4-10-19-26;/h2-20H,21H2,1H3;1H/q+1;/p-1

Upstream product

• 620-19-9 1-chloromethyl-3-methyl-benzene 
• 603-35-0 triphenylphosphine 

Downstream Products

• 82102-26-9 trans,trans-1-(m-methylphenyl)-4-phenyl-butadiene 
• 63368-25-2 3-Methyl-3'-benzyloxy-4'-methoxystilben 
• 204397-85-3 cyclo[2,2-dimethyl-β-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6R,7E)-5-hydroxy-6-methyl-8-(3-methylphenyl)-2,7-octadienoyl-3-chloro-O-methyl-D-tyrosyl] 
• 63368-03-6 3-Methyl-3'-hydroxy-4'-methoxydibenzyl 
• 802280-14-4 2-(3-methylstyryl)aniline 
• 15162-09-1 C₁₅H₁₃NO₂ 
• 14064-48-3 (E)-3-methylstilbene 
• 37163-81-8 (E)-1-methyl-3-(4-methylstyryl)benzene 

Relevant articles and documents

HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF

Heterocyclic compounds of Formula (I) and pharmaceutically acceptable salt thereof are disclosed. The use of such heterocyclic compounds and pharmaceutically acceptable salt thereof for the treatment of cancers, and more particularly cancers sensitive to mitochondrial activity inhibition and increased reactive oxygen species (ROS) levels, is also disclosed. Such cancers include acute myeloid leukemia (AML), preferably AML characterized by certain features, such as high level of expression of one or more Homeobox (HOX)-network genes, high and/or low expression of specific genes, the presence of one or more cytogenetic or molecular risk factors such as intermediate cytogenetic risk, Normal Karyotype (A/K), mutated NPM1, mutated CEBPA, mutated FLT3, mutated DNMT3A, mutated TET2, mutated IDH1, mutated IDH2, mutated RUNX1, mutated WT1, mutated SRSF2, intermediate cytogenetic risk with abnormal karyotype (intern(abnK)), trisomy 8 (+8) and/or abnormal chromosome (5/7), and/or a high leukemic stem cell (LSC) frequency.

Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators

Anti-inflammatory effects of liver X receptor (LXR) ligands are thought to be largely due to LXR-mediated transrepression, whereas side effects are caused by activation of LXR-responsive gene expression (transactivation). Therefore, selective LXR modulators that preferentially exhibit transrepression activity should exhibit anti-inflammatory properties with fewer side effects. Here, we synthesized a series of styrylphenylphthalimide analogues and evaluated their structure-activity relationships focusing on LXRs-transactivating-agonistic/antagonistic activities and transrepressional activity. Among the compounds examined, 17l showed potent LXR-transrepressional activity with high selectivity over transactivating activity and did not show characteristic side effects of LXR-transactivating agonists in cells. This representative compound, 17l, was confirmed to have LXR-dependent transrepressional activity and to bind directly to LXRβ. Compound 17l should be useful not only as a chemical tool for studying the biological functions of LXRs transrepression but also as a candidate for a safer agent to treat inflammatory diseases.

Chemical structure and sweet taste of isocoumarin and related compounds. IX

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