63412-06-6

Basic information

• Product Name: MNB
• Synonyms: MNB;N-Methyl-N-nitrosobenzamide;Anti-DYR1A, N-Terminal antibody produced in rabbit;Dual specificity YAK1-related kinase;hMNB;MNBH;Protein kinase minibrain homolog;Anti-DYRK1A (N-terminal) antibody produced in goat
• CAS NO: 63412-06-6
• Molecular Formula: C₈H₈N₂O₂
• Molecular Weight: 164.18
• Mol File: 63412-06-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 291.62°C (rough estimate)
• Flash Point: 99.7°C
• Appearance: /
• Density: 1.2739 (rough estimate)
• Vapor Pressure: 0.0361mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: -20°C
• PKA: -2.60±0.70(Predicted)
• CAS DataBase Reference: MNB(CAS DataBase Reference)
• NIST Chemistry Reference: MNB(63412-06-6)
• EPA Substance Registry System: MNB(63412-06-6)

Safety Data

• Hazardous Substances Data: 63412-06-6(Hazardous Substances Data)

Usage

General Description

N-Methyl-N-nitrosobenzamide is a chemical compound with the molecular formula C8H9N3O2. It is a member of the class of N-nitrosobenzamides, which are organic compounds that contain a benzamide moiety with the nitrosobenzene group attached at the N-atom. It is a potent carcinogen and a mutagen, and exposure to this compound has been linked to various adverse health effects, including cancer development. N-Methyl-N-nitrosobenzamide is primarily used as a research chemical and is not widely utilized in industrial applications due to its hazardous nature. It is important for individuals working with this compound to exercise caution and follow proper safety protocols to minimize the risk of exposure.

InChI:InChI=1/C8H8N2O2/c1-10(9-12)8(11)7-5-3-2-4-6-7/h2-6H,1H3

Upstream product

• 88070-48-8 N-methylbenzamide 
• 72017-01-7 N-Methylbenzimidchlorid 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1483-24-5 1-methyl-1-benzoylhydrazine 
• 88070-48-8 N-methylbenzamide 
• 55-21-0 benzamide 
• 93-58-3 benzoic acid methyl ester 
• 1759-68-8 N-benzoylcyclohexylamine 
• 614-17-5 N-ethylbenzamide 
• 13291-44-6 S-tert-butyl benzothioate 
• 100-68-5 methyl-phenyl-thioether 
• 884-09-3 phenyl thiobenzoate 
• 20308-70-7 1-(pyrrolidin-1-yl)nonan-1-one 
• 1696-17-9 N,N-diethylbenzamide 
• 2782-40-3 N-butylbenzamide 
• 1485-70-7 N-benzylbenzamide 
• 1484-17-9 S-ethyl thiobenzoate 

Relevant articles and documents

Tert -Butyl nitrite promoted transamidation of secondary amides under metal and catalyst free conditions

A mild and efficient method is demonstrated for the transamidation of secondary amides with various amines including primary, secondary, cyclic and acyclic amines in the presence of tert-butyl nitrite. The reaction proceeds through the N-nitrosamide intermediate and provides the transamidation products in good to excellent yields at room temperature. Moreover, the developed methodology does not require any catalyst or additives.

Tert-Butyl Nitrite-Mediated Synthesis of N-Nitrosoamides, Carboxylic Acids, Benzocoumarins, and Isocoumarins from Amides

This work reports tert-butyl nitrite (TBN) as a multitask reagent for (1) the controlled synthesis of N-nitrosoamide from N-alkyl amides, (2) hydrolysis of N-methoxyamides to carboxylic acids, (3) metal- and oxidant-free benzocoumarin synthesis from ortho-aryl-N-methoxyamides via N-H, C-N, and C-H bond activation, and (4) isocoumarin synthesis using Ru(II)/PEG as a recyclable catalytic system via ortho-C-H activation and TBN as an oxygen source. The sequential functional group interconversion of amide to acid has also been examined using IR spectroscopic analysis. Additionally, this methodology is highly advantageous due to short reaction time, gram scale synthesis, and broad substrate scope.

Selective N-nitrosation of amines, N-alkylamides and N-alkylureas by N2O4 supported on cross-linked polyvinylpyrrolidone (PVP-N2O4)

N2O4 was supported on the cross-linked polyvinylpyrrolidone (PVP) to afford a solid, stable and recyclable nitrosating agent. This reagent shows excellent selectivity for N-nitrosation of dialkyl amines in the presence of diaryl-, arylalkyl-, trialkylamines and also for secondary amides in dichloromethane at room temperature under mild and heterogeneous conditions. Also N-nitroso-N-alkyl amides can be selectively prepared in the presence of primary amides and N-phenylamides under similar reaction conditions. Selective N-nitrosation or dealkylation and N-nitrosation of tertiary amines can also be performed by this reagent.