6344-60-1 Usage
Description
1-Hydroxy-9H-fluoren-9-one is an organic compound that serves as an intermediate in the synthesis of Fluoren-1-ol (F462450), a metabolite of the polycyclic aromatic hydrocarbon (PAH) micropollutant Fluorene (F462002). 1-HYDROXY-9-FLUORENONE has potential mutagenic effects and is utilized as a biomarker to assess exposure to PAHs and environmental tobacco smoke in the general population.
Uses
Used in Environmental Monitoring:
1-Hydroxy-9H-fluoren-9-one is used as a biomarker for evaluating exposure to polycyclic aromatic hydrocarbons (PAHs) and environmental tobacco smoke in the general population. Its presence in biological samples can indicate the level of exposure to these harmful substances, which can be useful for public health assessments and environmental monitoring.
Used in Research and Development:
In the field of research and development, 1-Hydroxy-9H-fluoren-9-one is utilized as an intermediate in the synthesis of Fluoren-1-ol (F462450). This synthesized compound can be further studied for its potential mutagenic effects and its role in understanding the impact of PAH micropollutants on human health and the environment.
Synthesis Reference(s)
Tetrahedron Letters, 21, p. 4781, 1980 DOI: 10.1016/0040-4039(80)80138-9
Check Digit Verification of cas no
The CAS Registry Mumber 6344-60-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,4 and 4 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6344-60:
(6*6)+(5*3)+(4*4)+(3*4)+(2*6)+(1*0)=91
91 % 10 = 1
So 6344-60-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H8O2/c14-11-7-3-6-9-8-4-1-2-5-10(8)13(15)12(9)11/h1-7,14H
6344-60-1Relevant articles and documents
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Ando,W.,Kohmoto,S.
, p. 120 - 121 (1978)
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Cu(I)-catalyzed intramolecular cyclizations of substituted 2-iodobenzophenones under thermal and microwave conditions
Haggam, Reda A.
, p. 6488 - 6494 (2013/07/26)
Novel, easy-to-perform and practical intramolecular Cu(I)-catalyzed cyclizations of substituted 2-iodobenzophenones under thermal and microwave conditions are reported. The isolated cyclized products under microwave conditions are obtained with high yields and with short reaction times offering a valuable and reliable alternative to other protocols for the synthesis of fluorene analogues.
Synthesis of functionalized biaryls based on a heck cross-coupling-[3+3] cyclization strategy
Mro?, Gerson,Reinke, Helmut,Langer, Peter
scheme or table, p. 963 - 966 (2009/04/04)
6-Arylsalicylates were regioselectively prepared by formal [3+3] cyclization of 1,3-bis(silyloxy)-1,3-butadienes with 1-aryl-3-ethoxyprop-2-en-1- ones which are available by Heck reaction of benzoyl chlorides with ethylvinyl ether. In this context, the first [3+3] cyclizations of brominated substrates are reported. Georg Thieme Verlag Stuttgart.
