634469-41-3

Basic information

• Product Name: 4-Chloro-2-piperazin-1-yl-pyrimidine hydrochloride
• Synonyms: 4-CHLORO-2-PIPERAZIN-1-YL-PYRIMIDINE HYDROCHLORIDE;PyriMidine,4-chloro-2-(1-piperazinyl)-, hydrochloride
• CAS NO: 634469-41-3
• Molecular Formula: C8H12Cl2N4
• Molecular Weight: 235.11
• Mol File: 634469-41-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Chloro-2-piperazin-1-yl-pyrimidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-piperazin-1-yl-pyrimidine hydrochloride(634469-41-3)
• EPA Substance Registry System: 4-Chloro-2-piperazin-1-yl-pyrimidine hydrochloride(634469-41-3)

Safety Data

• Hazardous Substances Data: 634469-41-3(Hazardous Substances Data)

Usage

General Description

4-Chloro-2-piperazin-1-yl-pyrimidine hydrochloride is a chemical compound used in the pharmaceutical industry as an intermediate for the synthesis of potential antipsychotic and antidepressant drugs. It is a piperazine derivative with a chlorine-substituted pyrimidine ring, and its hydrochloride form is commonly used for its increased solubility in water. 4-Chloro-2-piperazin-1-yl-pyrimidine hydrochloride has been studied for its potential in treating various neurological and psychiatric disorders due to its ability to modulate serotonin and dopamine neurotransmission. Its unique structure and pharmacological properties make it a valuable building block for the development of novel therapeutics targeting mental health conditions.

InChI:InChI=1/C8H11ClN4.ClH/c9-7-1-2-11-8(12-7)13-5-3-10-4-6-13;/h1-2,10H,3-6H2;1H

Upstream product

• 479691-42-4 tert-butyl 4-(4-chloropyrimidin-2-yl)piperazine- 1-carboxylate 

Relevant articles and documents

HETEROCYCLYL COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE

The present invention relates to compounds of formula (I), wherein R1 to R3, A and Q are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof

The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I) in which: n is 1 or 2; p is 1 or 2; R1 represents a halogen atom; a trifluoromethyl radical; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethoxy radical; R2 represents a hydrogen atom or a halogen atom; R3 represents a hydrogen atom; a group —OR5; a group —CH2OR5; a group —NR6R7; a group —NR8COR9; a group —NR8CONR10R11; a group —CH2NR12R13; a group —CH2NR8CONR14R15; a (C1-C4)alkoxycarbonyl; a group —CONR16R17; or else R3 constitutes a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; R4 represents an aromatic group selected from: the said aromatic groups being unsubstituted or being mono- or disubstituted by a substituent selected independently from a halogen atom; a (C1-C4)alkyl; a (C1-C4)alkoxy; a trifluoromethyl radical; Preparation process and therapeutic application.