6345-63-7

Basic information

• Product Name: 2-nitrobenzylidene di(acetate)
• Synonyms: 2-nitrobenzylidene di(acetate);2-Nitrobenzaldiacetate;(2-Nitrophenyl)diacetoxymethane;(2-Nitrophenyl)methanediol diacetate;2-Nitro-1-(diacetoxymethyl)benzene;2-Nitrophenylmethanediol diacetate;Diacetic acid o-nitrobenzylidene ester;o-Nitrobenzal Diacetate 98%
• CAS NO: 6345-63-7
• Molecular Formula: C₁₁H₁₁NO₆
• Molecular Weight: 253.20814
• EINECS: 228-751-1
• Mol File: 6345-63-7.mol
• Article Data: 57

Chemical Properties

• Melting Point: 88-90 °C
• Boiling Point: 368.6°Cat760mmHg
• Flash Point: 161.9°C
• Appearance: /
• Density: 1.323g/cm³
• Vapor Pressure: 1.26E-05mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 2-nitrobenzylidene di(acetate)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitrobenzylidene di(acetate)(6345-63-7)
• EPA Substance Registry System: 2-nitrobenzylidene di(acetate)(6345-63-7)

Safety Data

• Hazardous Substances Data: 6345-63-7(Hazardous Substances Data)

Usage

Description

2-Nitrobenzylidene di(acetate) is an organic chemical compound characterized by a molecular formula of C11H9NO6. It features a benzene ring with a nitro group and two acetate groups attached, giving it a yellowish solid appearance and a melting point of approximately 144 degrees Celsius. 2-Nitrobenzylidene di(acetate) is recognized for its role as a chemical intermediate in the synthesis of organic compounds and pharmaceuticals, as well as its utility as a reagent in organic chemical reactions and a building block in dye and pigment manufacturing.

Uses

Used in Pharmaceutical Industry:
2-Nitrobenzylidene di(acetate) serves as a crucial chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Organic Synthesis:
As a reagent in organic chemical reactions, 2-Nitrobenzylidene di(acetate) facilitates the formation of desired products by participating in various reaction mechanisms. Its presence can enhance the efficiency and selectivity of these reactions, making it a valuable tool in organic synthesis.
Used in Dye and Pigment Manufacturing:
2-Nitrobenzylidene di(acetate) is utilized as a building block in the production of dyes and pigments. Its chemical properties enable it to contribute to the color and stability of these products, which are essential in various industries such as textiles, paints, and plastics.
It is important to handle 2-Nitrobenzylidene di(acetate) with care due to its potential hazards, including the risk of causing skin and eye irritation. Proper safety measures should be taken to minimize these risks during its use in various applications.

InChI:InChI=1/C11H11NO6/c1-7(13)17-11(18-8(2)14)9-5-3-4-6-10(9)12(15)16/h3-6,11H,1-2H3

Upstream product

• 88-72-2 1-methyl-2-nitrobenzene 
• 108-24-7 acetic anhydride 
• 552-89-6 2-nitro-benzaldehyde 
• 116274-79-4 6-(2-Nitro-phenyl)-6,7-dihydro-5H-5,7,7a,13-tetraaza-benzo[3,4]cyclohepta[1,2-b]naphthalen-8-one 
• 581-55-5 benzylidene 1,1-diacetate 
• 7664-93-9 sulfuric acid 
• 114-70-5 sodium phenylacetate 
• 99-61-6 3-nitro-benzaldehyde 

Downstream Products

• 94005-04-6 2-nitro-2'.4'.6'-trimethyl-trans-chalcone 
• 552-89-6 2-nitro-benzaldehyde 
• 7473-93-0 (E)-3-(2-nitrophenyl)-1-phenylprop-2-en-1-one 
• 555-16-8 4-nitrobenzaldehdye 
• 17994-61-5 3,4-dihydro-5-ethoxycarbonyl-4-(2-nitrophenyl)-6-methylpyrimidine-2(1H)-one 
• 571903-49-6 5-acetyl-6-methyl-3,4-dihydro-4-(2-nitrophenyl)pyrimidin-2(1H)-one 
• 1427213-33-9 C₁₈H₁₆N₂O₄ 
• 20939-77-9 2-acetamidobenzyl alcohol 

Relevant articles and documents

Chemoselective synthesis of 1,1-diacetates under solvent-free condition using efficient heterogeneous ecofriendly catalyst: P2O5/kaolin

An efficient and chemoselective method for the preparation of acylals from different aldehydes and acetic anhydride using.....kaolin supported catalyst (P2O5). under solvent-free conditions is described herein. The present protocol offers several advantages including use of inexpensive and non-toxic catalyst support i.e., natural kaolin. Preparation of the supported catalyst is easy, the process is simple in operation, maintaining solvent free conditions, with short reaction times, high yields and affording selective protection of aldehyde in presence of ketone.

Supported N-propylsulfamic acid onto Fe3O4 magnetic nanoparticles as a reusable and efficient nanocatalyst for the protection/deprotection of hydroxyl groups and protection of aldehydes

N-propylsulfamic acid supported onto Fe3O4 magnetic nanoparticles (MNPs-PSA) as an efficient and magnetically reusable nanocatalyst has been reported for the tetrahydropyranylation/depyranylation of a wide variety of alcohols and phenols by changing the solvent medium. Also, the protection of aldehydes as acylals using Ac2O in the presence of catalytic amount MNPs-PSA in good to high yields at room temperature under solvent-free conditions is described. After completing the reaction, the catalyst was easily separated from the reaction mixture with the assistance of an external magnetic field and reused for several consecutive runs without significant loss of their catalytic efficiency.

Zinc zirconium phosphate as an efficient catalyst for chemoselective synthesis of 1,1-diacetates under solvent-free conditions

In the present study, a mild, rapid, and efficient method for the protection of aldehydes with acetic anhydride (AA) in the presence of zinc zirconium phosphate (ZPZn) as a nano catalyst, at room temperature is reported. Selective conversion of aldehydes was observed in the presence of ketones. Under these conditions, different aldehydes bearing electron-withdrawing and electron-donating substituents were reacted with AA and the corresponding 1,1-diacetates (acylals) were obtained in high to excellent yields. The steric and electronic properties of the different substrates had a significant influence on the reaction conditions. Also, the deprotection of 1,1-diacetates has been achieved using this catalyst in water. This nanocatalyst was characterized by several physico-chemical techniques. It was recovered easily from the reaction mixture, regenerated and reused at least 7 times without significant loss in catalytic activity. This protocol has the advantages of easy availability, stability, reusability of the eco-friendliness, chemoselectivity, simple experimental and work-up procedure, solvent-free conditions and usage of only a stoichiometric amount of AA.