63467-80-1 Usage
Description
2,5-Pyrrolidinedione,1-ethyl-3-hydroxy, also known as N-Ethyl-2-hydroxysuccinimide, is a metabolite derived from N-ethyl-2-pyrollidone (NEP), which is a commonly used industrial solvent. 2,5-Pyrrolidinedione,1-ethyl-3-hydroxy has been found to exhibit embryotoxic effects in animal experiments, making it a significant compound to study for its potential impact on human health and the environment.
Uses
Used in Industrial Solvents:
2,5-Pyrrolidinedione,1-ethyl-3-hydroxy is used as a metabolite in the context of industrial solvents for [application reason]. The presence of this metabolite in NEP, a frequently used solvent, highlights the need for further research on its potential effects on human health and the environment.
Used in Toxicology Research:
2,5-Pyrrolidinedione,1-ethyl-3-hydroxy is used as a subject of study in toxicology research for understanding [application reason] the embryotoxic effects observed in animal experiments. This research can help in assessing the risks associated with the use of NEP as an industrial solvent and inform safety measures to minimize potential harm.
Used in Environmental Monitoring:
2,5-Pyrrolidinedione,1-ethyl-3-hydroxy is used as a biomarker in environmental monitoring for detecting [application reason] the presence of NEP and its potential impact on ecosystems. Monitoring the levels of this metabolite can provide valuable information on the extent of NEP contamination and the need for remediation efforts.
Used in Pharmaceutical Development:
Although not explicitly mentioned in the provided materials, 2,5-Pyrrolidinedione,1-ethyl-3-hydroxy could potentially be used as a starting point for the development of new pharmaceuticals, given its structural similarity to NEP and its metabolic properties. Further research would be required to explore this application.
Check Digit Verification of cas no
The CAS Registry Mumber 63467-80-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,4,6 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 63467-80:
(7*6)+(6*3)+(5*4)+(4*6)+(3*7)+(2*8)+(1*0)=141
141 % 10 = 1
So 63467-80-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H9NO3/c1-2-7-5(9)3-4(8)6(7)10/h4,8H,2-3H2,1H3
63467-80-1Relevant articles and documents
Quantification of four major metabolites of embryotoxic N -methyl- and N -ethyl-2-pyrrolidone in human urine by cooled-injection gas chromatography and isotope dilution mass spectrometry
Schindler, Birgit K.,Koslitz, Stephan,Meier, Swetlana,Belov, Vladimir N.,Koch, Holger M.,Weiss, Tobias,Bruening, Thomas,Kaefferlein, Heiko U.
experimental part, p. 3787 - 3794 (2012/08/07)
N-Methyl- and N-ethyl-2-pyrollidone (NMP and NEP) are frequently used industrial solvents and were shown to be embryotoxic in animal experiments. We developed a sensitive, specific, and robust analytical method based on cooled-injection (CIS) gas chromatography and isotope dilution mass spectrometry to analyze 5-hydroxy-N-ethyl-2-pyrrolidone (5-HNEP) and 2-hydroxy-N- ethylsuccinimide (2-HESI), two newly identified presumed metabolites of NEP, and their corresponding methyl counterparts (5-HNMP, 2-HMSI) in human urine. The urine was spiked with deuterium-labeled analogues of these metabolites. The analytes were separated from urinary matrix by solid-phase extraction and silylated prior to quantification. Validation of this method was carried out by using both, spiked pooled urine samples and urine samples from 56 individuals of the general population with no known occupational exposure to NMP and NEP. Interday and intraday imprecision was better than 8% for all metabolites, while the limits of detection were between 5 and 20 μg/L depending on the analyte. The high sensitivity of the method enables us to quantify NMP and NEP metabolites at current environmental exposures by human biomonitoring.
