63521-85-7

Basic information

• Product Name: Esorubicin
• Synonyms: Esorubicin;5,12-Naphthacenedione, 10-(2S,4R,6S)-4-aminotetrahydro-6-methyl-2H-pyran-2-yloxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-;4'-deoxydoxorubicin;(8S,10S)-10-[[(2S)-4α-Aminotetrahydro-6α-methyl-2H-pyran-2β-yl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione;4'-Deoxyadriamycin
• CAS NO: 63521-85-7
• Molecular Formula: C27H29NO10
• Molecular Weight: 527.523
• EINECS: 264-575-1
• Mol File: 63521-85-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 765.8°C at 760 mmHg
• Flash Point: 416.9°C
• Appearance: /
• Density: 1.55g/cm³
• Vapor Pressure: 1.16E-24mmHg at 25°C
• Refractive Index: 1.693
• PKA: 7.35±0.60(Predicted)
• CAS DataBase Reference: Esorubicin(CAS DataBase Reference)
• NIST Chemistry Reference: Esorubicin(63521-85-7)
• EPA Substance Registry System: Esorubicin(63521-85-7)

Safety Data

• Hazardous Substances Data: 63521-85-7(Hazardous Substances Data)

Usage

Uses

Antineoplastic.

InChI:InChI=1/C27H29NO10/c1-11-6-12(28)7-18(37-11)38-16-9-27(35,17(30)10-29)8-14-20(16)26(34)22-21(24(14)32)23(31)13-4-3-5-15(36-2)19(13)25(22)33/h3-5,11-12,16,18,29,32,34-35H,6-10,28H2,1-2H3/t11-,12+,16-,18-,27-/m0/s1

Relevant articles and documents

TARGETED DRUG DELIVERY USING SULFONAMIDE DERIVATIVES

The present invention relates to Glutathione S-transferase (GST)/Reduced Glutathione (GSH) as a means for the in-vivo release of a drug that has been conjugated to specific electrophilic moieties via a sulfonamide bond. The drug may be an anticancer agent (or one with other therapeutic properties) carrying a free —NH— which has been derivatized by the attachment of an electrophile containing a moiety, such as p-CN— or p-NO 2-pyridinylsulfonyl groups, or p-NO 2- or 2,4 dinitrophenylsulfonyl groups, or suitable derivatives thereof, to make a prodrug. Optionally, the sulfonamide moiety may have attached to it a targeting molecule. The present invention also provides Glutathione S-transferase (GST)/Reduced Gluthathione (GSH) as a means for the release of a protected amino derivative that has been conjugated to specific electrophilic moieties via a sulfonamide bond. The precursor is a synthetic intermediate carrying a free —NH— which has been derivatized by the attachment of an electrophile via a sulfonamide bond.

Anthracycline glycosides, their preparation and use

The novel compounds, 4'-deoxy-daunomycin and 4'-deoxy-adriamycin, as well as derivatives thereof are useful as anti-tumor antibiotics. These compounds are prepared by condensing the corresponding aglycone with a novel trifluoracetyl protected reactive halo sugar which is 2,3,4,6-tetradeoxy-3-trifluoroacetamido-L-threo-hexopyranosyl chloride.