635287-26-2 Usage
Description
Fmoc-NH-5(ethylene glycol)-acetic acid, also known as Fmoc-NH-PEG5-CH2COOH, is a PEG linker that features an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer enhances solubility in aqueous media, and the Fmoc group can be deprotected under basic conditions to reveal the free amine for subsequent conjugations. The terminal carboxylic acid is capable of reacting with primary amine groups in the presence of activators such as EDC or HATU, resulting in the formation of a stable amide bond.
Uses
Used in Bioconjugation:
Fmoc-NH-5(ethylene glycol)-acetic acid serves as a PEG linker for bioconjugation applications, providing a hydrophilic spacer that increases solubility and allows for the formation of stable amide bonds with primary amine groups.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Fmoc-NH-5(ethylene glycol)-acetic acid is utilized as a component in drug delivery systems, where its PEG spacer and reactive terminal carboxylic acid facilitate the attachment of therapeutic agents to improve their solubility, stability, and targeted delivery.
Used in Peptide Synthesis:
Fmoc-NH-5(ethylene glycol)-acetic acid is employed as a building block in peptide synthesis, where the Fmoc-protected amine can be selectively deprotected and used for the stepwise assembly of peptide sequences.
Used in Chemical Biology Research:
In chemical biology research, Fmoc-NH-5(ethylene glycol)-acetic acid is used as a versatile reagent for the synthesis of bioactive molecules and the study of protein-protein interactions, taking advantage of its PEG spacer and reactive functional groups.
Check Digit Verification of cas no
The CAS Registry Mumber 635287-26-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,3,5,2,8 and 7 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 635287-26:
(8*6)+(7*3)+(6*5)+(5*2)+(4*8)+(3*7)+(2*2)+(1*6)=172
172 % 10 = 2
So 635287-26-2 is a valid CAS Registry Number.
635287-26-2Relevant articles and documents
Method of inhibiting nonspecific interaction between molecules on solid phase support
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, (2008/06/13)
The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the hydrophobic property of the solid phase surface in the solid phase carrier is regulated, particularly a hydrophilic spacer is interlaid at the time of immobilization of the molecule onto the solid phase carrier, which method makes it possible to suppress the nonspecific interaction between the molecules, and to reduce nonspecific adsorption to the solid phase.
