635302-32-8

Basic information

• Product Name: 2-AMINO-5-ETHYL-3-THIOPHENECARBONITRILE
• Synonyms: 2-AMINO-5-ETHYL-3-THIOPHENECARBONITRILE;AKOS MSC-0406;2-AMINO-5-ETHYLTHIOPHENE-3-CARBONITRILE;3-Thiophenecarbonitrile, 2-aMino-5-ethyl-
• CAS NO: 635302-32-8
• Molecular Formula: C₇H₈N₂S
• Molecular Weight: 152.22
• Mol File: 635302-32-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 299.365 °C at 760 mmHg
• Flash Point: 134.851 °C
• Appearance: /
• Density: 1.208 g/cm³
• Storage Temp.: 2-8°C
• PKA: 0.21±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-ETHYL-3-THIOPHENECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-ETHYL-3-THIOPHENECARBONITRILE(635302-32-8)
• EPA Substance Registry System: 2-AMINO-5-ETHYL-3-THIOPHENECARBONITRILE(635302-32-8)

Safety Data

• Hazardous Substances Data: 635302-32-8(Hazardous Substances Data)

Usage

General Description

2-AMINO-5-ETHYL-3-THIOPHENECARBONITRILE is a chemical compound with the molecular formula C7H8N2S. It is a thiophene derivative containing an amino group, an ethyl group, and a carbonitrile group. 2-AMINO-5-ETHYL-3-THIOPHENECARBONITRILE is used in organic synthesis and pharmaceutical research, particularly in the development of new drugs and agrochemicals. It has potential applications in the treatment of various medical conditions, as well as in the development of new materials and chemical processes. Its unique structure and properties make it an important building block in the field of organic chemistry.

Upstream product

• 123-72-8 butyraldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 186792-85-8 2-[(2-nitrophenyl)amino]-thiophene-3-carbonitrile 
• 660861-88-1 2-(5-fluoro-2-nitrophenylamino)-5-ethylthiophene-3-carbonitrile 
• 61325-07-3 2-(4-Fluoro-2-nitroanilino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-nitrile 
• 61325-71-1 2-ethyl-4-(4-methyl-piperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine 

Relevant articles and documents

Facile pathway for synthesis of two efficient catalysts for preparation of 2-aminothiophenes and tetrahydrobenzo[b]pyrans

Abstract: We report here a new magnetically recyclable catalyst consisting of iron-substituted Keggin-type heteropolyacid (HPA) grafted on modified Fe3O4 nanoparticles. The synthesized hybrid nanomaterial exhibited the excellent catalytic efficiency in condensation reaction for the preparation of tetrahydrobenzo[b]pyrans under solvent-free conditions as well as in the synthesis of 2-aminothiophenes via Gewald reaction. It must be noted that, HPA supported magnetite nanoparticles catalyzed the preparation of tetrahydrobenzo[b]pyrans, whereas for Gewald reaction amine-functionalized magnetite nanoparticles acted as a catalyst. Different characterization techniques such as Fourier transform infrared (FT-IR), X-ray powder diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM) were used to characterize the hybrid nanomaterial. The reusability of catalyst was affirmed by using in consecutive runs for five times. Performance of prepared catalyst was compared with the various previously reported catalysts; the newly synthesized catalysts found to be most efficient with regard to reaction time, yield and ease of catalyst separation. Graphical Abstract: [Figure not available: see fulltext.].

Preparation of magnetically recyclable ZnFe2O4 nanoparticles by easy single-step co-precipitation method and their catalytic performance in the synthesis of 2-aminothiophenes

In this work, a new synthetic route for the preparation of ZnFe2O4 nanoparticles through the chemical co-precipitation using Fe2+ and Fe3+ ions in an alkaline solution was developed. The synthesized nanoparticles were characterized by XRD, FTIR, SEM, ICP-MS, DRS, TGA, VSM and elemental analysis. Characterization results confirmed the formation of single ZnFe2O4 phase, with an average particle size of 40?nm and a high saturation magnetization of 34?emu g?1. The prepared material was employed as a catalyst for the synthesis of 2-aminotiophene derivatives through the Gewald reaction. This thermally and chemically stable nanocatalyst is environmentally benign, economical and reusable which can be easily recovered using an external magnet. Therefore, it appears that this methodology can be simply extended for industrial purposes.

Thieno [2, 3-d] pyrimidine compound, preparation method thereof and application thereof

The invention relates to the field of organic synthesis and discloses a thieno [2, 3-d] pyrimidine compound and an application thereof. The structure of the thieno [2, 3-d] pyrimidine compound is shown in a formula (1), wherein R1 and R2 independently rep