63536-46-9

Basic information

• Product Name: 2(1H)-Quinoxalinone,1-ethyl-(9CI)
• Synonyms: 2(1H)-Quinoxalinone,1-ethyl-(9CI)
• CAS NO: 63536-46-9
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.1992
• Product Categories: QUINOLINONE
• Mol File: 63536-46-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 64-65 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 309.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• PKA: -0.39±0.70(Predicted)
• CAS DataBase Reference: 2(1H)-Quinoxalinone,1-ethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinoxalinone,1-ethyl-(9CI)(63536-46-9)
• EPA Substance Registry System: 2(1H)-Quinoxalinone,1-ethyl-(9CI)(63536-46-9)

Safety Data

• Hazardous Substances Data: 63536-46-9(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic compound

Structure

Contains a quinoxalinone ring with an ethyl substituent

Usage

Intermediate in the synthesis of various pharmaceuticals and organic compounds

Usage

Building block in the production of other chemical compounds (e.g. pesticides and dyes)

Potential

Biological activities

Applications

Medicinal chemistry and drug discovery

Note

Specific properties and uses may vary depending on the context and the specific research or industrial application.

Upstream product

• 74-96-4 ethyl bromide 
• 36818-07-2 ethyl 3-oxo-4H-quinoxaline-2-carboxylate 
• 1196-57-2 quinoxalin-2⁽¹⁾-one 
• 64-17-5 ethanol 
• 95-54-5 1,2-diamino-benzene 
• 1493-27-2 ortho-nitrofluorobenzene 
• 5428-05-7 n-(2-nitrophenyl)glycine ethyl ester 
• 59564-59-9 1,2,3,4-tetrahydroquinoxalin-2-one 
• 14003-34-0 3-methyl-2-oxo-1,2-dihydroquinoxaline 
• 75-00-3 chloroethane 
• 75-03-6 ethyl iodide 
• 1196-57-2 2-hydroxyquinoxaline 

Downstream Products

• 88392-55-6 1-ethyl-3-phenylquinoxalin-2(1H)-one 
• 1186527-86-5 3-(4-chlorophenyl)-1-ethylquinoxalin-2(1H)-one 
• 586348-21-2 ataquimast 
• 73148-14-8 1-ethyl-3-methylquinoxalin-2(1H)-one 

Relevant articles and documents

Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones

Herein, we report a practical electro-reductive protocol for the direct C–H cyanoalkylation of quinoxalin-2(1H)-ones via iminyl radical-mediated ring opening. These mild reactions proceed under metal-, reductant-, and reagent-free conditions to provide synthetically useful cyanoalkylated quinoxalin-2(1H)-ones.

N, N, N', N'-Tetramethylethylenediamine-Enabled Photoredox-Catalyzed C-H Methylation of N-Heteroarenes

Aiming at the valuable methylation process, readily available and inexpensive N,N,N′,N′-tetramethylethylenediamine (TMEDA) was first identified as a new methyl source in photoredox-catalyzed transformation in this work. By virtue of this simple methylating reagent, a facile and practical protocol for the direct C-H methylation of N-heteroarenes was developed, featuring mild reaction conditions, broad substrate scope, and scalability. Mechanistic studies disclosed that a sequential photoredox, base-assisted proton shift, fragmentation, and tautomerization process was essentially involved.

Eosin Y as a direct hydrogen-atom transfer photocatalyst for the C3-H acylation of quinoxalin-2(1H)-ones

Visible light promoted eosin Y catalyzed selective C3-H acylation of quinoxalin-2(1H)-ones has been developed in a green and sustainable manner. In contrast to the conventional anionic eosin Y-based photoredox process, neutral eosin Y acts as the actual c