63590-63-6 Usage
General Description
2-Chloro-6-methoxyquinazolin-4-amine is a chemical compound with the molecular formula C9H8ClN3O originating from the Quinazoline group of chemicals. It is characterized by a single chlorine atom, a methoxy group and an amine group attached to the quinazoline core. 2-Chloro-6-methoxyquinazolin-4-amine may be used as an intermediate in the preparation of various other complex organic compounds. It is generally categorized under heterocyclic compounds, which comprise a significant portion of current pharmaceuticals. The properties or potential uses of 2-chloro-6-methoxyquinazolin-4-amine specifically can vary widely depending on the context of its use, particularly in the pharmaceutical industry where it has potential applications in drug synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 63590-63-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,5,9 and 0 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 63590-63:
(7*6)+(6*3)+(5*5)+(4*9)+(3*0)+(2*6)+(1*3)=136
136 % 10 = 6
So 63590-63-6 is a valid CAS Registry Number.
63590-63-6Relevant articles and documents
Process for preparing quinazolines
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, (2008/06/13)
2-Halo-4-aminoquinazolines are produced by a two-step process involving cyclization of 1-phenyl-3-cyanoureas or 1-phenyl-3-cyanothioureas in the presence of phosphorus halides and phosphorus oxyhalides to provide a phosphoquinazoline intermediate which is hydrolyzed to the quinazoline. Exemplary of the process is the intramolecular cyclization of 1-(3,4-dimethoxyphenyl)-3-cyanourea in the presence of phosphorus pentachloride and phosphorus oxychloride to a phosphoquinazoline intermediate which is subsequently hydrolyzed with formic acid to 2-chloro-4-amino-6,7-dimethoxy-quinazoline. The 2-halo-4-aminoquinazolines of the instant process are particularly valuable as intermediates in the preparation of 4-amino-2-(4-substituted-piperazin-l-yl)quinazolines useful in the treatment of cardiovascular disease, e.g. hypertension.
