63592-85-8

Basic information

• Product Name: Methyl 4-Chloronicotinate
• Synonyms: methyl 4-chloronicotinate;4-Chloronicotinicacidmethylester;4-Chloropyridine-3-carboxylic acid methyl ester;Methyl 4-chloronicotinate hydrochloride;3-Pyridinecarboxylic acid, 4-chloro-, Methyl ester;Methyl 4-chloropyridine-3-carboxylate;3-Carbomethoxy-4-chloropyridine;4-Chloro-3-pyridinecarboxylic acid methyl ester
• CAS NO: 63592-85-8
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.58
• Mol File: 63592-85-8.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 227℃
• Flash Point: 91℃
• Appearance: /
• Density: 1.294
• Vapor Pressure: 0.078mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 1.81±0.10(Predicted)
• CAS DataBase Reference: Methyl 4-Chloronicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-Chloronicotinate(63592-85-8)
• EPA Substance Registry System: Methyl 4-Chloronicotinate(63592-85-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 63592-85-8(Hazardous Substances Data)

Usage

Uses

Methyl 4-chloronicotinate, HCl

InChI:InChI=1/C7H6ClNO2/c1-11-7(10)5-4-9-3-2-6(5)8/h2-4H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 10177-29-4 4-chloronicotinic acid 
• 74-88-4 methyl iodide 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 100791-00-2 4-chloronicotinoyl chloride 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 151322-66-6 methyl 4-biphenyl-4-yl>methyl>amino>pyridine-3-carboxylate 
• 157362-09-9 4-{Propyl-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-nicotinic acid methyl ester 
• 845671-56-9 4-phenoxy-nicotinic acid methyl ester 
• 1055897-41-0 methyl 4-(benzylamino)nicotinate 
• 1387572-95-3 2-{[2-bromo-4-(trifluoromethyl)phenyl]sulfonyl}-1,3,4,10b-tetrahydropyrido[4',3':3,4]pyrrolo[1,2-a]pyrazin-6(2H)-one 
• 1387568-72-0 2-{[4-(trifluoromethyl)phenyl]sulfonyl}-1,3,4,10b-tetrahydropyrido[4',3':3,4]pyrrolo[1,2-a]pyrazin-6(2H)-one 
• 1387568-74-2 2-{[2-methyl-4-(trifluoromethyl)phenyl]sulfonyl}-1,3,4,10b-tetrahydropyrido[4',3':3,4]pyrrolo[1,2-a]pyrazin-6(2H)-one 
• 1454913-56-4 4-(4-chloro-2-fluorophenyl)nicotinic acid 
• 1454913-55-3 methyl 4-(4-chloro-2-fluorophenyl)nicotinate 

Relevant articles and documents

Unimolecular Anion-Binding Catalysts for Selective Ring-Opening Polymerization of O-carboxyanhydrides

Anion-binding can regulate anion transport in chloride channels through dynamic non-covalent interactions, which gives insights into the designing of new organocatalytic transformations but is surprisingly unexplored in polymerization catalysis. Herein, we describe an effective unimolecular anion-binding organocatalysis where 4-(dimethylamino)pyridine is anchored to a thiourea for ring-opening polymerization of O-carboxyanhydrides (OCAs) to furnish highly isotactic poly(phenyllactic acid) (Ph-PLA) with molecular weight (MW) up to 150.0 kDa, which well addresses the formidable challenge of synthesizing high MW stereoregular polyesters. Calculations and experimental studies indicate a dynamic cooperative anion-binding mechanism, where the dynamic anion-binding interaction of thiourea moiety to propagating species facilitates efficient chain propagation and the synergetic decarboxylation retains high selectivity for OCA ring-opening over side reactions (such as cyclization, epimerization, and transesterification).

INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR

The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor.

Indole derivative serving as CRTH2 inhibitor

The invention discloses an indole derivative serving as a CRTH2 inhibitor shown as a formula (I) as shown in the specification or pharmaceutically acceptable salts, as well as application of the indole derivative in treatment of diseases related to the CR