636-46-4

Basic information

• Product Name: 4-Hydroxyisophthalic acid
• Synonyms: HYDROXYISOPHTHALIC ACID, 4-;4-HYDROXYISOPHTHALIC ACID;4-HYDROXYBENZENE-1,3-DICARBOXYLIC ACID;4-HYDROXY-1,3-BENZENEDECARBOXYLIC ACID;4-HYDROXY-1,3-BENZENEDICARBOXYLIC ACID;ACETYLSALISYLIC ACID IMP B;4-hipa;4-hydroxy-3-benzenedicarboxylicacid
• CAS NO: 636-46-4
• Molecular Formula: C₈H₆O₅
• Molecular Weight: 182.13
• EINECS: 211-258-0
• Product Categories: Phthalic Acids, Esters and Derivatives;API intermediates;Aromatics;Impurities;Aromatics, Impurities
• Mol File: 636-46-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: >300°C
• Boiling Point: 310 C
• Flash Point: 238.6 °C
• Appearance: White powder
• Density: 1.4411 (rough estimate)
• Vapor Pressure: 8.58E-09mmHg at 25°C
• Refractive Index: 1.5690 (estimate)
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 2?+-.0.10(Predicted)
• Water Solubility: 0.3g/L(24 oC)
• Merck: 14,4827
• CAS DataBase Reference: 4-Hydroxyisophthalic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxyisophthalic acid(636-46-4)
• EPA Substance Registry System: 4-Hydroxyisophthalic acid(636-46-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-22-36/38
• Safety Statements: 26-36/37/39-36-39-6
• WGK Germany: 3
• RTECS: NT2544000
• Hazardous Substances Data: 636-46-4(Hazardous Substances Data)

Usage

Description

4-Hydroxyisophthalic acid, also known as 4-Hydroxy-1,3-benzenedicarboxylic acid, is an organic compound with the molecular formula C8H6O5. It is a white powder and is used as a pharmaceutical secondary standard for quality control in the pharmaceutical industry. 4-Hydroxyisophthalic acid has been proposed as an improvement over aspirin, specifically as an alternative to Acetylsalicylic acid (A187780), also known as Aspirin Impurity B.

Uses

Used in Pharmaceutical Industry:
4-Hydroxyisophthalic acid is used as a pharmaceutical secondary standard for quality control. It provides pharmaceutical laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. This application ensures the accuracy and reliability of pharmaceutical products, contributing to their overall safety and efficacy.
Used in Pain Relief and Anti-Inflammatory Applications:
4-Hydroxyisophthalic acid has been proposed as an improvement over aspirin, which is a widely used medication for pain relief, fever reduction, and inflammation. As an alternative to Acetylsalicylic acid (A187780), it may offer enhanced benefits in terms of efficacy, safety, or other pharmacological properties, potentially leading to better treatment outcomes for patients.
Used in Research and Development:
As a compound with potential applications in the pharmaceutical industry, 4-Hydroxyisophthalic acid may also be used in research and development efforts. Scientists and researchers can explore its properties, interactions, and potential uses in various therapeutic areas, contributing to the advancement of medical knowledge and the development of new drugs and treatments.

InChI:InChI=1/C8H6O5/c9-6-2-1-4(7(10)11)3-5(6)8(12)13/h1-3,9H,(H,10,11)(H,12,13)/p-2

Upstream product

• 90844-13-6 4-hydroxyisophthalic acid 1-ethyl ester 
• 88-61-9 2,4-dimethylbenzenesulfonic acid 
• 583-70-0 1-bromo-2,4-dimethylbenzene 
• 2206-43-1 4-methoxyisophthalic acid 
• 5985-24-0 dimethyl 4-hydroxyisophthalate 
• 4315-09-7 4-nitroisophthalic acid 
• 616-76-2 2-hydroxy-5-formylbenzoic acid 
• 5985-25-1 4-hydroxy-1,3-benzenedicarboxylic acid diethyl ester 
• 584-87-2 3-formyl-4-hydroxybenzoic acid 
• 85392-08-1 2-hydroxy-5-(2,2,2-trichloro-1-hydroxy-ethyl)-benzoic acid 
• 33555-64-5 2-hydroxy-5-phenylacetyl-benzoic acid 
• 33890-03-8 4-aminoisophthalic acid 
• 54176-51-1 5-bromo-4-hydroxyisophthalic acid dimethyl ester 
• 92865-42-4 dipropyl-4-hydroxy-1,3-benzenedicarboxylate 

Downstream Products

• 5985-24-0 dimethyl 4-hydroxyisophthalate 
• 79128-78-2 2-hydroxy-5-(methoxycarbonyl)benzoic acid 
• 41684-11-1 4-hydroxy-3-(methoxycarbonyl)benzoic acid 
• 91144-00-2 4-hydroxy-isophthalic acid 1-propyl ester 
• 92865-42-4 dipropyl-4-hydroxy-1,3-benzenedicarboxylate 
• 90844-13-6 4-hydroxyisophthalic acid 1-ethyl ester 
• 5985-25-1 4-hydroxy-1,3-benzenedicarboxylic acid diethyl ester 
• 616-76-2 2-hydroxy-5-formylbenzoic acid 
• 855641-74-6 5-formyl-4-hydroxy-isophthalic acid 
• 22235-27-4 4-hydroxy-5-nitro-isophthalic acid 
• 101567-41-3 4-hydroxy-cyclohexane-1,3-dicarboxylic acid 
• 54471-90-8 5-bromo-4-hydroxyisophthalic acid 
• 5985-26-2 4-(acetoxy)isophthalic acid 
• 99856-49-2 5-dimethylaminomethyl-4-hydroxy-isophthalic acid 

Relevant articles and documents

Method for extracting 4-hydroxy-m-phthalic acid from wintergreen oil production waste slag

The invention discloses a method for extracting 4-hydroxy-m-phthalic acid from wintergreen oil production waste slag. The method comprises the following steps: 1. extraction of 4-hydroxy-dimethyl isophthalate crude product from wintergreen oil production waste slag: dissolving wintergreen oil production waste slag in an organic solvent, heating, filtering while the solution is hot, standing the filtrate to precipitate a solid, and drying the filter cake to obtain the 4-hydroxy-dimethyl isophthalate crude product; 2. hydrolysis of 4-hydroxy-dimethyl isophthalate crude product: adding the 4-hydroxy-dimethyl isophthalate crude product into an alkali solution, heating for hydrolysis, cooling to room temperature, adding a decolorant for decolorization, regulating the pH value of the filtrate to 1-4, precipitating a solid under acidic conditions, collecting the filter cake, and carrying out vacuum drying. By recycling the wintergreen oil production waste slag, the method enhances the resource utilization rate and lowers the 4-hydroxy-m-phthalic acid production cost. Besides, the method has the advantages of high yield, high purity, simple technique, mild conditions, no side reaction and the like.

NOVEL CEPHALOSPORIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF

The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.