63775-95-1

Basic information

• Product Name: Cyclosporin B
• Synonyms: CYCLOSPORIN B;Ala2-cyclosporine;Antibiotic S 7481F2;Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alanyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl];(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Ala-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-);Cyclosporine IMpurity-B;7-L-Alaninecyclosporine A;Cyclosporin B (9CI)
• CAS NO: 63775-95-1
• Molecular Formula: C61H109N11O12
• Molecular Weight: 1188.58
• Product Categories: Intermediates & Fine Chemicals;Peptides;Pharmaceuticals
• Mol File: 63775-95-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 149-152°C
• Boiling Point: 1289.7°C at 760 mmHg
• Flash Point: 733.8°C
• Appearance: Amorphous white solid
• Density: 1.019g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.468
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.32±0.70(Predicted)
• CAS DataBase Reference: Cyclosporin B(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclosporin B(63775-95-1)
• EPA Substance Registry System: Cyclosporin B(63775-95-1)

Safety Data

• Hazardous Substances Data: 63775-95-1(Hazardous Substances Data)

Usage

Description

Cyclosporin B is a minor analogue of the cyclosporin complex, which is produced by various fungal genera such as Trichoderma, Tolypocladium, Fusarium, Nectria, and Acremonium. It is known for its immunosuppressant and antifungal properties, although it has not been as extensively studied as its major analogue, cyclosporin A.

Uses

Used in Organ Transplantation:
Cyclosporin B is used as an immunosuppressant in the medical field, particularly for revolutionizing organ transplantation. It plays a crucial role in the prevention of graft rejection, ensuring the success of transplant procedures.
Used in Pharmaceutical Applications:
Cyclosporin B is utilized as a group of nonpolar cyclic oligopeptides with immunosuppressant activity. This makes it a valuable compound for the development of new drugs and therapies in the pharmaceutical industry, targeting various immune-related conditions and diseases.

InChI:InChI=1/C61H109N11O12/c1-25-26-27-39(14)51(74)50-55(78)64-41(16)56(79)66(18)32-47(73)67(19)43(28-33(2)3)54(77)65-48(37(10)11)60(83)68(20)44(29-34(4)5)53(76)62-40(15)52(75)63-42(17)57(80)69(21)45(30-35(6)7)58(81)70(22)46(31-36(8)9)59(82)71(23)49(38(12)13)61(84)72(50)24/h25-26,33-46,48-51,74H,27-32H2,1-24H3,(H,62,76)(H,63,75)(H,64,78)(H,65,77)/b26-25+/t39?,40-,41+,42+,43+,44+,45+,46+,48+,49+,50-,51?/m1/s1