63815-42-9

Basic information

• Product Name: 1-(4-ethoxyphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride (1:1)
• Synonyms: 1-(4-Ethoxyphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride (1:1); 1-propanone, 1-(4-ethoxyphenyl)-3-(1-piperidinyl)-, hydrochloride (1:1)
• CAS NO: 63815-42-9
• Molecular Formula: C₁₆H₂₄ClNO₂
• Molecular Weight: 297.8203
• Mol File: 63815-42-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 398.2°C at 760 mmHg
• Flash Point: 194.6°C
• Vapor Pressure: 1.5E-06mmHg at 25°C
• CAS DataBase Reference: 1-(4-ethoxyphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-ethoxyphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride (1:1)(63815-42-9)
• EPA Substance Registry System: 1-(4-ethoxyphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride (1:1)(63815-42-9)

Safety Data

• Hazardous Substances Data: 63815-42-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-ethoxyphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride (1:1) is used as a chemical intermediate for the development of new pharmaceuticals. Its unique structure, which includes a piperidine ring and an ethoxyphenyl group, may contribute to its potential as a therapeutic agent.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(4-ethoxyphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride (1:1) is used as a starting material or a building block for the synthesis of more complex molecules with potential therapeutic properties. Its structural features make it a valuable compound for designing new drugs targeting various medical conditions.
Used in Drug Development:

Upstream product

• 50-00-0 formaldehyd 
• 6091-44-7 piperidine hydrochloride 
• 1676-63-7 4'-ethoxyacetophenone 

Relevant articles and documents

Synthesis of hypolipidemic evaluation of β-alkylaminopropiophenone and β-alkylaminopropio-2'-naphthone derivatives in rodents

A series of β-alkylamino-(4'-alkyl)-propiophenone or β-alkylamino(7'-methyl)-propio-2'-naphthone derivatives were prepared and found to have hypolipidemic activity by lowering both serum cholesterol and triglyceride levels in rodents. The electron donating substituent at the para position of the phenyl ring seems to decrease the hypolipidemic activity when compared to non-substituted or electron withdrawing group substituted analogs as investigated previously in this laboratory. In comparison with lovastatin or clofibrate, most of these analogs showed similar or higher activity in lowering both serum cholesterol or triglyceride levels. β-Pyrrolidino-(4'-methyl)-propiophenone (1) demonstrated the best activity after 16 d, i.p. administration in mice at 8 mg/kg/d. Further detailed studies in rats indicated that β-pyrrolidino-(4'-methyl)-propiophenone also showed decreased serum cholesterol and triglyceride levels with increased HDL-cholesterol and triglyceride levels after 14 d. In hyperlipidemic mice and rats, this compound was observed to be effective in lowering serum lipid levels as well as tissue lipid levels. The activities of hepatic acetyl CoA synthetase, phosphatidylate phosphohydrolase, and hepatic lipoprotein lipase were moderately inhibited by β-pyrrolidino-(4'-methyl)-propiophenone.