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638220-35-6

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638220-35-6 Usage

General Description

Methyl 1-(4-bromophenyl)cyclopropanecarboxylate is a chemical compound with the molecular formula C11H11BrO2. It is an ester, which means it is derived from an acid in which at least one hydrogen atom is replaced by an alkyl group. Methyl 1-(4-bromophenyl)cyclopropanecarboxylate has a cyclopropane ring, which is a highly strained and reactive three-membered ring. The presence of the bromophenyl group indicates that it contains a benzene ring with a bromine atom attached to it. Methyl 1-(4-bromophenyl)cyclopropanecarboxylate may have applications in organic synthesis, pharmaceuticals, or agrochemicals due to its unique structure and functional groups. It is important to handle this compound with caution and follow proper safety protocols when working with it in a laboratory or industrial setting.

Check Digit Verification of cas no

The CAS Registry Mumber 638220-35-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,3,8,2,2 and 0 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 638220-35:
(8*6)+(7*3)+(6*8)+(5*2)+(4*2)+(3*0)+(2*3)+(1*5)=146
146 % 10 = 6
So 638220-35-6 is a valid CAS Registry Number.

638220-35-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 1-(4-bromophenyl)cyclopropane-1-carboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:638220-35-6 SDS

638220-35-6Relevant articles and documents

Lysophosphatidic acid receptor antagonists and preparation method thereof

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Paragraph 0192-0193, (2020/07/29)

The invention belongs to the technical field of medicinal chemistry, and particularly relates to lysophosphatidic acid receptor antagonists and a preparation method thereof. The applicant surprisinglyfinds that compounds provided by the invention have high LPAR1 antagonistic activity and selectivity, low toxicity, good metabolic stability and good drug development prospect, and can be used for preventing or treating diseases or symptoms related to LPAR1. The applicant also accidentally finds that the IC50 value of part of the compounds can be as low as 300 nM or below and even 50 nM or below.Moreover, the compounds disclosed by the invention have better safety, and the CC50 range of the compounds can reach 200 [mu]M or above. In addition, the compounds of the present invention have goodmetabolic stability in humans, rats, and mice, such excellent inhibitory activity being very desirable for their use as LPAR1 inhibitors in the above diseases or disorders. In addition, the preparation method of the compounds is simple, mild in reaction condition, high in product yield and suitable for industrial production.

Electrophilic Bromolactonization of Cyclopropyl Diesters Using Lewis Basic Chalcogenide Catalysts

Gieuw, Matthew H.,Leung, Vincent Ming-Yau,Ke, Zhihai,Yeung, Ying-Yeung

supporting information, p. 4306 - 4311 (2018/10/02)

An efficient and regioselective electrophilic bromolactonization of cyclopropylmethyl diesters using triphenylphosphine sulfide (Ph3PS) or diphenyl selenide (Ph2Se) as the Lewis basic chalcogenide catalyst has been developed. It was observed that Ph3PS favored the formation of anti-diastereomer and yielded the multi-functional γ-lactones. Interestingly, the diastereoselectivity was reversed when using Ph2Se as a catalyst where the syn-product instead of the anti-product was favored. (Figure presented.).

SPIRO-SUBSTITUTED OXINDOLE DERIVATIVES HAVING AMPK ACTIVITY

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Page/Page column 128, (2015/01/07)

The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

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