63875-06-9

Basic information

• Product Name: 1-Methyl-2-phenyl-4-(trifluoromethyl)-1H-imidazole
• Synonyms: 1-Methyl-2-phenyl-4-(trifluoromethyl)-1H-imidazole
• CAS NO: 63875-06-9
• Molecular Formula: C₁₁H₉F₃N₂
• Molecular Weight: 226.1977696
• Mol File: 63875-06-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Methyl-2-phenyl-4-(trifluoromethyl)-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-2-phenyl-4-(trifluoromethyl)-1H-imidazole(63875-06-9)
• EPA Substance Registry System: 1-Methyl-2-phenyl-4-(trifluoromethyl)-1H-imidazole(63875-06-9)

Safety Data

• Hazardous Substances Data: 63875-06-9(Hazardous Substances Data)

Usage

General Description

1-Methyl-2-phenyl-4-(trifluoromethyl)-1H-imidazole is a chemical compound that belongs to the imidazole class of heterocyclic compounds. It is characterized by a methyl group, a phenyl group, and a trifluoromethyl group attached to the imidazole ring. 1-Methyl-2-phenyl-4-(trifluoromethyl)-1H-imidazole has potential applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting various biological processes. It may also have use as a building block for the synthesis of other biologically active molecules. The trifluoromethyl group is known for its ability to enhance the pharmacokinetic properties and improve the metabolic stability of drug molecules, and as such, 1-Methyl-2-phenyl-4-(trifluoromethyl)-1H-imidazole may hold promise for future drug discovery efforts.

Upstream product

• 161670-75-3 4-hydroxy-1-methyl-2-phenyl-4-trifluoromethyl-4,5-dihydroimidazole 
• 2568-34-5 N-benzoyl-N-methylglycine 
• 14119-99-4 4-trifluoroacetyl-3-methyl-2-phenyl-1,3-oxazol-3-ium-5-olate 

Relevant articles and documents

4-trifluoroacetyl-2-phenyloxazol-5-one: Versatile template for syntheses of trifluoromethylsubstituted heterocycles

4-Trifluoroacetyl-2-phenyloxazol-5-one (1) is a versatile template for the synthesis of various trifluoromethyl-substituted heterocycles. Cyclocondesation of 1 with hydroxylamine and hydrazine afforded isoxazole and pyrazole, respectively. Another key protocol involves nucleophilic ring opening of 1 with H2O or MeOH to give a-amido trifluoromethyl ketones which are transformed into trifluoromethyl-substituted thiazoles, oxazoles, imidazoles, pyrazoles, and pyrimidines.

Convenient synthesis of 5-trifluoroacetylated imidazoles by ring transformation of mesoionic 1,3-oxazolium-5-olates

Mesoionic 4-trifluoroacetyl-1,3-oxazolium-5-olates (1), obtained from the reaction of N-acyl-N-alkylglycines (2) with trifluoroacetic anhydride, react with amidines to give 5-trifluoroacetylimidazoles (3) in moderate yield. The novel ring transformations of 1 into 3 occur via an initial attack of amidines on the C-2 position of the ring.

A Novel Ring Transformation of Mesoionic 1,3-Oxazolium-5-olates into 5-Trifluoroacetylated and 5-Perfluoroacylated Imidazoles by Reaction with Amidines

Treatment of mesoionic 1,3-oxazolium-5-olates with amidines causes a novel ring transformation affording 5-trifluoroacetyl- and 5-perfluoroacyl-imidazoles in moderate yields.