639000-16-1

Basic information

• Product Name: (2-methoxy-5-nitro-phenyl)-propynal
• Synonyms: (2-methoxy-5-nitro-phenyl)-propynal
• CAS NO: 639000-16-1
• Molecular Weight: 205.17
• Mol File: 639000-16-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-methoxy-5-nitro-phenyl)-propynal(CAS DataBase Reference)
• NIST Chemistry Reference: (2-methoxy-5-nitro-phenyl)-propynal(639000-16-1)
• EPA Substance Registry System: (2-methoxy-5-nitro-phenyl)-propynal(639000-16-1)

Safety Data

• Hazardous Substances Data: 639000-16-1(Hazardous Substances Data)

Upstream product

• 5399-03-1 2-iodo-1-methoxy-4-nitrobenzene 

Relevant articles and documents

A New Preparative Route to Substituted Dibenzofurans by Benzannulation Reaction. An Application to the Synthesis of Cannabifuran

A new regioselective pathway to substituted dibenzofuran derivatives is described here. According to this procedure substituted 1-acetoxy-3- alkoxycarbonyl dibenzofurans are obtained by treatment of 6-(2-methoxyaryl)-3- alkoxycarbonylhex-3-en-5-ynoic acids with acetic anhydride in the presence of sodium acetate. The latter acids are prepared from the easily available substituted o-iodo-anisoles by Sonogashira coupling with propargylic alcohol and Wittig reaction as the key steps. The described benzannulation reaction proceeds in regioselective fashion and a range of substituents are tolerated. Its synthetic utility is demonstrated by a new synthesis of cannabifuran, a naturally occurring dibenzofuran.