63906-63-8 Usage
Description
1-N-PROPYL-3,7-DIMETHYLXANTHINE, also known as propentofylline, is a xanthine derivative of caffeine with potential therapeutic effects on various conditions such as Alzheimer's disease, Parkinson's disease, and stroke. It possesses anti-inflammatory, neuroprotective, and cognition-enhancing properties, which are attributed to its ability to inhibit phosphodiesterase activity and antagonize adenosine receptors, resulting in increased levels of cyclic adenosine monophosphate (cAMP) and adenosine.
Uses
Used in Pharmaceutical Industry:
1-N-PROPYL-3,7-DIMETHYLXANTHINE is used as a therapeutic agent for the treatment of neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke. Its neuroprotective and cognition-enhancing properties make it a promising candidate for improving cognitive function and reducing inflammation in these conditions.
Used in Research and Development:
1-N-PROPYL-3,7-DIMETHYLXANTHINE is utilized in preclinical and clinical studies to investigate its potential mechanisms of action and medical applications. Further research is needed to fully understand its therapeutic effects and optimize its use in treating various conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 63906-63-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,9,0 and 6 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 63906-63:
(7*6)+(6*3)+(5*9)+(4*0)+(3*6)+(2*6)+(1*3)=138
138 % 10 = 8
So 63906-63-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N4O2/c1-4-5-14-9(15)7-8(11-6-12(7)2)13(3)10(14)16/h6H,4-5H2,1-3H3
63906-63-8Relevant articles and documents
Predictable stereoselective and chemoselective hydroxylations and epoxidations with P450 3A4
Larsen, Aaron T.,May, Erin M.,Auclair, Karine
supporting information; experimental part, p. 7853 - 7858 (2011/06/26)
Enantioselective hydroxylation of one specific methylene in the presence of many similar groups is debatably the most challenging chemical transformation. Although chemists have recently made progress toward the hydroxylation of inactivated C-H bonds, enzymes such as P450s (CYPs) remain unsurpassed in specificity and scope. The substrate promiscuity of many P450s is desirable for synthetic applications; however, the inability to predict the products of these enzymatic reactions is impeding advancement. We demonstrate here the utility of a chemical auxiliary to control the selectivity of CYP3A4 reactions. When linked to substrates, inexpensive, achiral theobromine directs the reaction to produce hydroxylation or epoxidation at the fourth carbon from the auxiliary with pro-R facial selectivity. This strategy provides a versatile yet controllable system for regio-, chemo-, and stereoselective oxidations at inactivated C-H bonds and demonstrates the utility of chemical auxiliaries to mediate the activity of highly promiscuous enzymes.
Analogue of Coffeine and Theophylline: Effect of Structural Alterations on Affinity at Adenosine Receptors
Daly, J. W.,Padgett, W. L.,Shamim, M. T.
, p. 1305 - 1308 (2007/10/02)
A variety of analogues of caffeine and theophylline in which the 1-, 3-, and 7-methyl substituents have been replaced with n-propyl, allyl, propargyl, and isobutyl and, in few cases with chloroethyl, hydroxyethyl, or benzyl were assessed for potency and s
