640-57-3

Basic information

• Product Name: Benzene,1-methyl-4-(phenylsulfonyl)-
• Synonyms: Sulfone,phenyl p-tolyl (6CI,7CI,8CI);4-(Phenylsulfonyl)toluene;4-Methyldiphenylsulfone;4-Methylphenyl phenyl sulfone;NSC 2724;NSC 633012;NSC 91059;Phenylp-tolyl sulfone;p-Methyldiphenyl sulfone;p-Tolyl phenyl sulfone
• CAS NO: 640-57-3
• Molecular Formula: C₁₃H₁₂O₂S
• Molecular Weight: 232.2982
• EINECS: 211-364-7
• Mol File: 640-57-3.mol
• Article Data: 143

Chemical Properties

• Melting Point: 127-129°C
• Boiling Point: 387.9 °C at 760 mmHg
• Flash Point: 229.7 °C
• Appearance: /
• Density: 1.196 g/cm³
• Vapor Pressure: 7.12E-06mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 1872872
• CAS DataBase Reference: Benzene,1-methyl-4-(phenylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene,1-methyl-4-(phenylsulfonyl)-(640-57-3)
• EPA Substance Registry System: Benzene,1-methyl-4-(phenylsulfonyl)-(640-57-3)

Safety Data

• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.
• RTECS: WR6880000
• TSCA: Yes
• Hazardous Substances Data: 640-57-3(Hazardous Substances Data)

Usage

Uses

p-Methyldiphenyl Sulfone is a derivative of diphenyl sulfone

Synthesis Reference(s)

The Journal of Organic Chemistry, 32, p. 2931, 1967 DOI: 10.1021/jo01284a075Synthesis, p. 283, 1984

InChI:InChI=1/C13H12O2S/c1-11-7-9-13(10-8-11)16(14,15)12-5-3-2-4-6-12/h2-10H,1H3

Upstream product

• 3699-01-2 4-tolyl phenyl sulfide 
• 640-60-8 toluene-4-sulfonic acid phenyl ester 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 103151-64-0 4-[N-(toluene-4-sulfonyl)-anilino]-butyric acid 
• 10506-59-9 dimethyl disulfate 
• 104-15-4 toluene-4-sulfonic acid 
• 71-43-2 benzene 
• 42840-02-8 2-(Toluene-4-sulfonylamino)-benzoyl chloride 
• 60-29-7 diethyl ether 
• 98-09-9 benzenesulfonyl chloride 
• 108-88-3 toluene 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 98-59-9 p-toluenesulfonyl chloride 
• 2674-04-6 diphenyl cadmium 

Downstream Products

• 860699-53-2 2-tosylbenzoic acid 
• 103626-97-7 5-methyl-2,2'-sulfonyl-di-benzoic acid 
• 536-57-2 p-toluene sulfinic acid 
• 5361-54-6 4-(phenylsulfonyl)benzoic acid 
• 7705-63-7 1-(bromomethyl)-4-(phenylsulfonyl)benzene 
• 83859-32-9 4-tolyl phenyl selenide 
• 854637-15-3 2,4-bis-benzenesulfonyl-toluene 
• 101597-95-9 1-benzenesulfonyl-4-diacetoxymethyl-benzene 
• 13333-14-7 4,4'-Di-benzolsulfonyl-stilben 
• 53348-83-7 C₂₈H₂₂O₂S 
• 13350-35-1 p--stilben 
• 13319-05-6 4-Methoxy-4'-benzolsulfonyl-stilben 
• 13333-13-6 p-Phenylsulfonyl-p'-N,N-dimethylamino-stilben 
• 53178-81-7 p-Phenylsulfonyl-α-nitrotoluol 

Relevant articles and documents

Dispersible porous classical polymer photocatalysts for visible light-mediated production of pharmaceutically relevant compounds in multiple solvents

The dispersibility of photocatalytic polymeric materials is currently a limiting factor for wide scale use. Indeed, the dispersibility of photocatalytic material in solvents dictates its use as heterogenous catalysts, due in part to reagent solubility. Here, we describe a new platform for producing porous polymer photocatalytic nanoparticles that are easily dispersible in a broad range of solvents. Photocatalytic porous classical polymer nanoparticles have been designed, based on classical porous nanoparticles copolymerised with photocatalytic moieties. The combination of both classical and photocatalytic monomers results in an affordable highly photocatalytically effective material, that can be easily dispersed in a wide range of solvents. The versatility and useability of this new material has been demonstrated by photocatalysing a number of pharmaceutically relevant compounds in solvents with varying polarity.

Metal-free sulfonylation of arenes with: N -fluorobenzenesulfonimide via cleavage of S-N bonds: expeditious synthesis of diarylsulfones

A novel metal-free sulfonylation of arenes with N-fluorobenzenesulfonimide (NFSI) toward the synthesis of diarylsulfones has been developed. The reaction represents a rare example of sulfonylation reaction using NFSI as an efficient sulfonyl donor and the first example of acid-mediated sulfonylation of unactivated arenes with NFSI via selective cleavage of S-N bonds. This protocol provides a concise approach for the construction of pharmaceutically and biologically important diarylsulfones. Applications in the functionalization of natural products (e.g., β-estradiol) and in the synthesis of a key intermediate to an inhibitor of farnesyl-protein transferase, as well as in the gram-scale synthesis of the EPAC2 antagonist, are demonstrated. This journal is

Synergistic cooperative effect of CF3SO2Na and bis(2-butoxyethyl)ether towards selective oxygenation of sulfides with molecular oxygen under visible-light irradiation

A safe, practical and eco-friendly method for the switchable synthesis of sulfoxides and sulfones through visible-light-initiated oxygenation of sulfides at ambient temperature under transition-metal-, additives-free and minimal solvent conditions. The synergistic catalytic efforts between CF3SO2Na and 2-butoxyethyl ether represents the key promoting factor for the reaction. This journal is