64230-41-7

Basic information

• Product Name: 1H-Pyrrole-2-carboxamide,1-methyl-(9CI)
• Synonyms: 1H-Pyrrole-2-carboxamide,1-methyl-(9CI);1-Methylpyrrole-2-carboxamide;1-Methyl-1H-pyrrole-2-carboxamide
• CAS NO: 64230-41-7
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.142
• Product Categories: AMIDE
• Mol File: 64230-41-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 1H-Pyrrole-2-carboxamide,1-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboxamide,1-methyl-(9CI)(64230-41-7)
• EPA Substance Registry System: 1H-Pyrrole-2-carboxamide,1-methyl-(9CI)(64230-41-7)

Safety Data

• Hazardous Substances Data: 64230-41-7(Hazardous Substances Data)

Usage

Structure

A heterocyclic aromatic organic compound with a pyrrole ring and a 1-methyl substitution.

Usage

Commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds.

Applications

Has potential applications in the fields of medicine, agrochemicals, and materials science.

Unique properties

The 1-methyl substitution on the pyrrole ring gives this compound unique properties that make it valuable for use in various chemical processes and as a precursor for the synthesis of other compounds.

Upstream product

• 131452-48-7 Cyano-(1-methyl-1H-pyrrol-2-yl)-acetic acid methyl ester 
• 96-54-8 N-Methylpyrrole 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 1192-58-1 N-methylpyrrole aldehyde 
• 379240-80-9 (1-methyl-1H-pyrrole-2-carbonyl)-phosphoramidic acid 
• 37619-24-2 methyl N-methylpyrrole-2-carboxylate 
• 216320-88-6 N-(1-methylpyrrole-2-carboxy)amidophosphoric dichloride 
• 131452-45-4 Cyano-[5-hydroxy-1-methyl-pyrrolidin-(2E)-ylidene]-acetic acid methyl ester 
• 131452-46-5 Cyano-[5-methoxy-1-methyl-pyrrolidin-(2E)-ylidene]-acetic acid methyl ester 
• 21898-65-7 1-methyl-2-trichloroacetyl-1H-pyrrole 
• 6973-60-0 1-Methyl-2-pyrrolecarboxylic acid 

Downstream Products

• 69807-81-4 2-aminomethyl-1-methyl-1H-pyrrole 
• 126092-97-5 methyl 4-<<<4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrole-2-carboxylate 

Relevant articles and documents

Inter- and intramolecular hydrogen bonds - Structures of 1-methylpyrrole-2-carboxamide and 1-hydroxypyrrole-2-carboxamide

The structures of 1-methylpyrrole-2-carboxamide (MPCA) and 1-hydroxypyrrole-2-carboxamide (HPCA) are analyzed, for both structures B3LYP/6-311++G(d,p) calculations were performed on s-cis and s-trans conformations and on monomeric and dimeric forms of these conformers. N-H?O hydrogen bonds exist for dimers. The X-ray crystal structure of MPCA is also analyzed; centrosymmetric dimers of syn conformers connected through N-H?O hydrogen bonds exist in crystal structure as well as C-H?O intramolecular interactions possessing some of characteristics typical for hydrogen bond.

Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides to Form Nitriles

A palladium(II) catalyst, in the presence of Selectfluor, enables the efficient and chemoselective transformation of primary amides into nitriles. The amides can be attached to aromatic rings, heteroaromatic rings, or aliphatic side chains, and the reactions tolerate steric bulk and electronic modification. Dehydration of a peptaibol containing three glutamine groups afforded structure-activity relationships for each glutamine residue. Thus, this dehydration can act similarly to an alanine scan for glutamines via synthetic mutation.

Direct conversion of aldehydes to amides, tetrazoles, and triazines in aqueous media by one-pot tandem reactions

A variety of aldehydes reacted with iodine in ammonia water at room temperature to give the nitrile intermediates, which were trapped by addition of hydrogen peroxide, sodium azide, or dicyandiamide to produce their corresponding amides, tetrazoles, and 1,3,5-triazines in modest to high yields. The one-pot tandem reactions were conducted in water media, and the products were obtained simply by extraction or filtration.