643-77-6

Basic information

• Product Name: Benzeneacetic acid, a-fluoro-, ethyl ester
• CAS NO: 643-77-6
• Molecular Formula: C10H11FO2
• Molecular Weight: 182.195
• Mol File: 643-77-6.mol
• Article Data: 40

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, a-fluoro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, a-fluoro-, ethyl ester(643-77-6)
• EPA Substance Registry System: Benzeneacetic acid, a-fluoro-, ethyl ester(643-77-6)

Safety Data

• Hazardous Substances Data: 643-77-6(Hazardous Substances Data)

Upstream product

• 31491-20-0 (1-ethoxy-2-phenylvinyloxy)trimethylsilane 
• 64-17-5 ethanol 
• 1578-63-8 d'acide 2-fluoro-2-phenyl acetique 
• 774-40-3 hydroxy-phenyl-acetic acid ethyl ester 
• 19242-50-3 ethyl 3-hydroxy-2-phenylprop-2-enoate 
• 4870-65-9 2-bromophenylacetic acid 
• 3389-53-5 phenylacetylpyrrolidine 
• 108-86-1 bromobenzene 
• 401-56-9 ethyl chlorofluoroacetate 
• 3262-89-3 triphenylboroxine 
• 100701-49-3 3-ethoxy-2-fluoro-3-oxopropionic acid 
• 17097-90-4 2-phenylmalonic acid monoethyl ester 
• 401-55-8 ethyl bromofluoroacetate 
• 780-69-8 triethoxyphenylsilane 

Downstream Products

• 29114-82-7 1-Fluoro-1-phenyl-hexan-2-one 
• 21120-43-4 1-phenyl-1-fluoro-2-propanone 
• 3468-99-3 ethyl diphenylacetate 
• 1578-63-8 d'acide 2-fluoro-2-phenyl acetique 
• 1126-71-2 N,N-dimethylphenethylamine 
• 14204-06-9 α-fluoro-N,N-dimethylbenzeneacetamide 
• 14204-07-0 2-fluoro-2-phenylacetamide 
• 14204-09-2 N_.N-Dimethyl-2-fluor-2-phenyl-aethylamin 
• 63818-95-1 S(+)-acide fluoro-2 phenyl-2 acetique 
• 63818-94-0 (R)-α-fluoro-α-phenylacetic acid 
• 1578-78-5 α-fluoro-α-phenylmalonic acid 
• 247039-05-0 (R_S)-(+)-2-[N-(p-toluenesulfinamido)]-3-(S)-fluoro-3-phenylpropionitrile 
• 247039-08-3 (R_S)-(-)-2-[N-(p-toluenesulfinamido)]-3-(R)-fluoro-3-phenylpropionitrile 

Relevant articles and documents

Nickel-Catalyzed Cross-Coupling of Ethyl Chlorofluoroacetate with Aryl Bromides

A combinatorial nickel-catalyzed monofluoroalkylation of aryl bromides with the industrial raw regent ethyl chlorofluoroacetate has been developed. The two key factors to successful conversion are the combination of nickel with readily available nitrogen and phosphine ligands and the using of a mixture of different solvents. Mechanistic investigations indicated a new zinc regent might generated in situ and be involved in the reaction process.

Organo-catalyzed Michael addition of 2-fluoro-2-arylacetonitriles

An efficient synthesis of a variety of 2-arylacetonitriles containing a fluorinated stereogenic center through organo-catalyzed Michael addition reaction of 2-fluoro-2-arylacetonitriles has been developed. This protocol uses a cheap organocatalyst (DBU) and has a broad substrate scope: α, β-unsaturated ketones, esters, nitriles and sulfones were all successfully reacted. Importantly, water proved to be a good solvent for this reaction.

AZABICYCLO AND DIAZEPINE DERIVATIVES FOR TREATING OCULAR DISORDERS

The present invention provides in one aspect azabicycio and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator. Formulae (I) & (II):