64358-50-5 Usage
Description
4'-AMINOMETHYL-4,5',8-TRIMETHYLPSORALEN is a bioactive molecule characterized by its ability to intercalate into double-stranded DNA. This unique property allows it to interact with genetic material, making it a promising candidate for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
4'-AMINOMETHYL-4,5',8-TRIMETHYLPSORALEN is used as a therapeutic agent for its DNA-intercalating properties, which can potentially be harnessed for the development of novel treatments targeting genetic disorders or diseases with a genetic component.
Used in Research and Development:
In the field of research, 4'-AMINOMETHYL-4,5',8-TRIMETHYLPSORALEN serves as a valuable tool for studying the interactions between small molecules and DNA. This can lead to a better understanding of the molecular mechanisms underlying various genetic conditions and the development of targeted therapies.
Used in Drug Design and Development:
The DNA-intercalating property of 4'-AMINOMETHYL-4,5',8-TRIMETHYLPSORALEN makes it a useful compound in the design and development of new drugs, particularly those aimed at treating cancer or other diseases with a genetic basis. Its ability to interact with DNA can be exploited to create molecules that target specific genetic sequences or structures, potentially leading to more effective and selective treatments.
Used in Diagnostic Applications:
4'-AMINOMETHYL-4,5',8-TRIMETHYLPSORALEN's interaction with DNA can also be utilized in the development of diagnostic tools and tests. By designing molecules that specifically bind to certain DNA sequences or structures, it may be possible to create highly sensitive and specific diagnostic assays for the detection of genetic mutations or the presence of specific pathogens.
Check Digit Verification of cas no
The CAS Registry Mumber 64358-50-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,3,5 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 64358-50:
(7*6)+(6*4)+(5*3)+(4*5)+(3*8)+(2*5)+(1*0)=135
135 % 10 = 5
So 64358-50-5 is a valid CAS Registry Number.
64358-50-5Relevant articles and documents
Design and Application of Mini-libraries of miRNA Probes for an Efficient and Versatile miRNA-mRNA Cross-linking
Hall, Jonathan,Laski, Artur,Malinowska, Anna L.
, p. 10193 - 10200 (2021/06/08)
MicroRNAs constitute a class of endogenous, non-coding RNAs that influence various processes within the cell. By base-pairing to partially-complementary sites located in the 3’ untranslated region of target messenger RNAs, microRNAs participate in post-transcriptional regulation of the majority of human protein-coding genes. Their dysregulation has been related to many pathological processes and diseases. Thus, an in-depth understanding of the microRNA mechanisms of action is crucial. Here, we present a new concept of probe design to achieve an efficient and sequence-independent miRNA-mRNA cross-linking. The new strategy is based on the utilization of a controlled mixture of probes for a chosen miRNA, in which a trioxsalen moiety is introduced at the N4-position of a selected cytidine through short oligoethylene glycol-based linkers. In vitro photo-cross-linking experiments with mini-libraries of probes for microRNAs of interest showed variable cross-linking efficiencies, demonstrating a general applicability of the presented approach.
Aminomethyl psoralens. Electrophilic substitutions of hydroxymethylphthamide on linear furocoumarins
Heindel,Choudhuri,Ressner,Foster
, p. 73 - 76 (2007/10/02)
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