64371-43-3

Basic information

• Product Name: Methanone, diphenyl-, O-[2-(dimethylamino)-1-methylethyl]oxime
• CAS NO: 64371-43-3
• Molecular Formula: C18H22N2O
• Molecular Weight: 282.385
• Mol File: 64371-43-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methanone, diphenyl-, O-[2-(dimethylamino)-1-methylethyl]oxime(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, diphenyl-, O-[2-(dimethylamino)-1-methylethyl]oxime(64371-43-3)
• EPA Substance Registry System: Methanone, diphenyl-, O-[2-(dimethylamino)-1-methylethyl]oxime(64371-43-3)

Safety Data

• Hazardous Substances Data: 64371-43-3(Hazardous Substances Data)

Upstream product

• 574-66-3 Benzophenone oxime 
• 4584-49-0 (2-chloropropyl)dimethylamine hydrochloride 

Relevant articles and documents

Synthesis of various geometric and enantiomeric oxime O-(α and β methylcholinyl) ethers as potential anticholinergic agents

Various enantiomeric and geometric oxime O (α and β methylcholinyl) ethers were synthesized as potential anticholinergic agents. The synthesis, separation, resolution, and structural characterization of these compounds are reported. The first step of the synthetic pathway involved an oxime formation, with subsequent O alkylation of the respective oxime with 2 chloro N,N dimethylpropylamine hydrochloride. The separation of the α and β structural isomers utilized vacuum fractional distillation and/or column chromatography, and the resolution of the enantiomers was accomplished via the formation of tartrate diastereoisomers. A preliminary pharmacological evaluation for anticholinergic activity was conducted using a rat ileum assay. Structure activity relationships, including some stereochemical properties and antimuscarinic activity, are discussed.