64488-12-6

Basic information

• Product Name: 2-CYANO-N-(4-METHYLBENZYL)ACETAMIDE
• Synonyms: 2-CYANO-N-(4-METHYLBENZYL)ACETAMIDE;2-cyano-N-[(4-methylphenyl)methyl]acetamide;2-cyano-N-[(4-methylphenyl)methyl]ethanamide
• CAS NO: 64488-12-6
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.22578
• Mol File: 64488-12-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 126-128
• Boiling Point: 432.7 °C at 760 mmHg
• Flash Point: 215.5 °C
• Appearance: /
• Density: 1.101 g/cm³
• Vapor Pressure: 1.08E-07mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-CYANO-N-(4-METHYLBENZYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-N-(4-METHYLBENZYL)ACETAMIDE(64488-12-6)
• EPA Substance Registry System: 2-CYANO-N-(4-METHYLBENZYL)ACETAMIDE(64488-12-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 64488-12-6(Hazardous Substances Data)

Usage

General Description

2-CYANO-N-(4-METHYLBENZYL)ACETAMIDE is a chemical compound with the molecular formula C12H13N3O. It is a derivative of acetamide and contains a cyano group and a methylbenzyl group. 2-CYANO-N-(4-METHYLBENZYL)ACETAMIDE has applications in the field of pharmaceuticals and organic synthesis. It is often used as a building block in the synthesis of various pharmaceutical and agrochemical products. Its chemical structure and properties make it useful for creating new compounds with potentially beneficial biological activities. However, it is important to handle this chemical with proper precautions and follow safety guidelines while working with it in a laboratory setting.

InChI:InChI=1/C11H12N2O/c1-9-2-4-10(5-3-9)8-13-11(14)6-7-12/h2-5H,6,8H2,1H3,(H,13,14)

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 104-84-7 para-methylbenzylamine 
• 105-34-0 methyl 2-cyanoacetate 

Downstream Products

• 1001088-74-9 (E)-2-cyano-N-(4-methylbenzyl)-3-(5-(3-nitrophenyl)furan-2-yl)acrylamide 

Relevant articles and documents

Synthesis and Cytotoxicity of Octahydroepoxyisoindole-7-carboxylic Acids and Norcantharidin–Amide Hybrids as Norcantharidin Analogues

Octahydroepoxyisoindole analogues of norcantharidin were accessed through a Diels–Alder reaction of an amine-substituted furan with maleic anhydride and subsequent reduction of the bicyclo[2.2.1]heptene olefin. Despite retention of the carboxylate and the ether bridgehead known to impart cytotoxic activity to norcantharidin, none of these analogues displayed notable cytotoxicity against the 11 cell lines examined: HT29 (colon), MCF-7 (breast), A2780 (ovarian), H460 (lung), A431 (skin), Du145 (prostate), BE2-C (neuroblastoma), SJ-G2 and U87 (glioblastoma), MIA (pancreatic), and SMA (spontaneous murine astrocytoma). The incorporation of an amino-substituted system post-synthesis of norcantharidin afforded facile access to 14 acid/amide-substituted norcantharidin analogues. Of these, only four displayed sufficient activity at the initial 25 μm compound screening dose to warrant full evaluation of growth inhibition. Common to these analogues was the presence of a 4-biphenyl moiety, and in particular 3-(2-(furan-2-ylmethyl)-3-(4-biphenylamino)-3-oxopropylcarbamoyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid (13 c) and 3-(2-(pyrrole-2-ylmethyl)-3-(4-biphenylamino)-3-oxopropylcarbamoyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid (24) displayed high levels of cytotoxicity, returning GI50 values of 15 nm (HT29) to 2.9 μm (U87) and 17 nm (SMA) to 2.8 μm (U87), respectively. These are the most cytotoxic norcantharidin analogues reported to date.

Tyrphostin-like compounds with ubiquitin modulatory activity as possible therapeutic agents for multiple myeloma

With the goal of developing small molecules as novel regulators of signal transduction and apoptosis, a series of tyrphostin-like compounds were synthesized and screened for their activity against MM-1 (multiple myeloma) cells and other cell lines representing this malignancy. Synthesis was completed in solution-phase initially and then adopted to solid-phase for generating a more diverse set of compounds. A positive correlation was noted between compounds capable of inducing apoptosis and their modulation of protein ubiquitination. Further analysis suggested that ubiquitin modulation occurs through inhibition of cellular deubiquitinase activity. Bulky groups on the sidechain near the α,β-unsaturated ketone caused a complete loss of activity, whereas cyclization on the opposite side was tolerated. Theoretical calculations at the B3LYP/LACV3P** level were completed on each molecule, and the resulting molecular orbitals and Fukui reactivity values for Cβ carbon were utilized in developing a model to explain the compound activity.

Derivatives of 3-carboxy pyrid-2-ones

Novel compounds belonging to the class of 1-substituted benzylpyrid-2-one-4,6-dialkyl and 4,5,6-trisubstituted-3-carboxylic acids, amides, esters and physiologically acceptable salts. These compounds possess biological activity and in particular are gametocides and plant growth regulators. Novel 1-substituted benzyl-3-cyano-4,5,6-trisubstituted pyrid-2-ones are also disclosed as intermediates.