644997-81-9

Basic information

• Product Name: (R)-((S)-Indan-1-ylamino)-phenyl-acetonitrile
• Synonyms: (R)-((S)-Indan-1-ylamino)-phenyl-acetonitrile
• CAS NO: 644997-81-9
• Molecular Weight: 248.327
• Mol File: 644997-81-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-((S)-Indan-1-ylamino)-phenyl-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-((S)-Indan-1-ylamino)-phenyl-acetonitrile(644997-81-9)
• EPA Substance Registry System: (R)-((S)-Indan-1-ylamino)-phenyl-acetonitrile(644997-81-9)

Safety Data

• Hazardous Substances Data: 644997-81-9(Hazardous Substances Data)

Upstream product

• 644997-79-5 (R)-2-[Indan-(1E)-ylideneamino]-2-phenyl-acetamide 
• 83-33-0 inden-1-one 
• 700-63-0 (R)-phenylglycine amide 
• 644997-80-8 (R)-2-((S)-Indan-1-ylamino)-2-phenyl-acetamide 

Downstream Products

• 10277-74-4 (S)-1-Aminoindane 

Relevant articles and documents

(S)-1-aminoindane: Synthesis by chirality transfer using (R)-phenylglycine amide as chiral auxiliary

A practical asymmetric synthesis of nearly enantiomerically pure (S)-1-aminoindane has been developed. The key step involves the diastereoselective heterogeneous metal-catalyzed reduction of the ketimine of 1-indanone with the chiral auxiliary (R)-phenylglycine amide. The selectivity of the asymmetric hydrogenation step was optimized with regard to metal catalyst, solvent and catalyst loading. The chiral auxiliary was removed by means of a novel non-reductive procedure. Thus, (S)-1-aminoindane with an ee of 96% was prepared in 58% overall yield from (R)-phenylglycine amide in an effective three-step procedure.