6452-47-7 Usage
Description
Methylaminoformyl chloride is an organic compound that serves as a versatile reagent in the synthesis of various chemical compounds and pharmaceuticals. It is known for its role in the production of carbamate insecticides and as a component in the synthesis of potential dual-binding site acetylcholinesterase inhibitors.
Uses
Used in Pesticide Industry:
Methylaminoformyl chloride is used as an intermediate in the synthesis of carbamate insecticides such as Zhongdingwei, carbofuran, isoprocarb, methomyl, chlorhexidine, and carbaryl. These insecticides are widely used in agriculture to control pests and protect crops.
Used in Pharmaceutical Industry:
Methylaminoformyl chloride is used as a reagent in the synthesis of acylprolinamides, which are a new class of peptide deformylase inhibitors with in vivo antibacterial activity. These inhibitors have potential applications in the development of new antibiotics to combat bacterial infections.
Used in the Synthesis of Acetylcholinesterase Inhibitors:
Methylaminoformyl chloride is also used as a reagent in the synthesis of carbamate derivatives, which have potential as dual-binding site acetylcholinesterase inhibitors. These inhibitors could be used in the treatment of neurological disorders, such as Alzheimer's disease, by enhancing the effects of the neurotransmitter acetylcholine in the brain.
Used in Cartap Synthesis:
The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is useful during the synthesis of cartap, a compound that has potential applications in various chemical processes.
Preparation
Methylaminoformyl chloride is prepared by reacting methylamine with phosgene. Reaction equation: CH3NH2+COCl2→CH3NHCOCl. A 40% aqueous solution of methylamine is vaporized, and after drying, it is combined with phosgene at a ratio of 1:1.3 (methanol), methylamine at 4 m3/h, and phosgene at a rate of 8.6 m3/h (content 60%-70%). Preheating into the preheater, the preheating temperature of methylamine is controlled at 220-260°C, and the phosgene is controlled at 200-240°C. The preheated two gases enter the test tube and are synthesized at 280-300°C to obtain gaseous methaqualyl chloride. Then, carbon tetrachloride (or chlorobenzene solution) is circulated and absorbed at 0-20°C to obtain a solution of about 10% of carbamoyl chloride (or chlorobenzene), or cooled to a liquid product after 35-40°C or lower[2,3].
Synthesis Reference(s)
Journal of the American Chemical Society, 72, p. 1888, 1950 DOI: 10.1021/ja01161a009
Check Digit Verification of cas no
The CAS Registry Mumber 6452-47-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,5 and 2 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6452-47:
(6*6)+(5*4)+(4*5)+(3*2)+(2*4)+(1*7)=97
97 % 10 = 7
So 6452-47-7 is a valid CAS Registry Number.
InChI:InChI=1/C2H4ClNO/c1-4-2(3)5/h1H3,(H,4,5)
6452-47-7Relevant articles and documents
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Buder,Schmidt
, p. 1429,1430, 1434 (1973)
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Preparation of carbamoyl halides
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, (2008/06/13)
Compounds of formula I, RNHCOCl (I), where R is an optionally substituted alkyl or aryl group, are obtained by chlorinating a compound of formula II, RNHCHO (II), in the absence of a solvent.
Preparation of alkyl isocyanates
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, (2008/06/13)
A novel process for the preparation of alkyl isocyanates comprising reacting COX2 and an alkyl amine hydrohalide of the formula wherein R is alkyl of 1 to 3 carbon atoms and X is a halogen either under pressure in an inert organic solvent or under atmospheric pressure in a high boiling organic solvent to form the corresponding alkyl carbamoyl halide, reacting the latter in an organic solvent with an urea of the formula STR1 wherein X' is selected from the group consisting of oxygen and sulfur, R1 and R3 are individually selected from the group consisting of alkyl of 1 to 7 carbon atoms, cycloalkyl of 4 to 6 carbon atoms and phenyl and R2 and R4 are individually selected from the group consisting of hydrogen, alkyl of 1 to 7 carbon atoms, cycyloalkyl of 4 to 6 carbon atoms and phenyl to obtain the corresponding alkyl isocyanate.