645352-55-2

Basic information

• Product Name: Glycine, N-ethyl-N-(3-hydroxyphenyl)-, 1,1-dimethylethyl ester
• CAS NO: 645352-55-2
• Molecular Formula: C14H21NO3
• Molecular Weight: 251.326
• Mol File: 645352-55-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Glycine, N-ethyl-N-(3-hydroxyphenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-ethyl-N-(3-hydroxyphenyl)-, 1,1-dimethylethyl ester(645352-55-2)
• EPA Substance Registry System: Glycine, N-ethyl-N-(3-hydroxyphenyl)-, 1,1-dimethylethyl ester(645352-55-2)

Safety Data

• Hazardous Substances Data: 645352-55-2(Hazardous Substances Data)

Upstream product

• 591-27-5 m-Hydroxyaniline 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 621-31-8 3-(ethylamino)phenol 

Downstream Products

• 645352-57-4 [ethyl-(4-formyl-3-hydroxy-phenyl)-amino]-acetic acid tert-butyl ester 

Relevant articles and documents

Detection of Amines and Unprotected Amino Acids in Aqueous Conditions by Formation of Highly Fluorescent Iminium Ions

Properly substituted coumarin aldehydes can be used to detect amines and amino acids under neutral, high ionic strength conditions by the formation of highly fluorescent iminium ions. The fluorescence of one sensor increases by 26-fold upon the addition o

Enhanced NIR radiation-triggered hyperthermia by mitochondrial targeting

Mitochondria are organelles that are readily susceptible to temperature elevation. We selectively delivered a coumarin-based fluorescent iron oxide nanoparticle, Mito-CIO, to the mitochondria. Upon 740 nm laser irradiation, the intracellular temperature of HeLa cells was elevated by 2.1 °C within 5 min when using Mito-CIO, and the treatment resulted in better hyperthermia and a more elevated cytotoxicity than HeLa cells treated with coumarin iron oxide (CIO), which was missing the mitochondrial targeting unit. We further confirmed these results in a tumor xenograft mouse model. To our knowledge, this is the first report of a near-infrared laser irradiation-induced hyperthermic particle targeted to mitochondria, enhancing the cytotoxicity in cancer cells. Our present work therefore may open a new direction in the development of photothermal therapeutics.