64603-91-4 Usage
Description
THIP HYDROCHLORIDE, also known as Gaboxadol HCl, is a GABA-A receptor agonist with the chemical formula (64603-91-4). It is primarily recognized for its hypnotic properties and is used as a therapeutic agent in the treatment of various conditions.
Uses
Used in Pharmaceutical Industry:
THIP HYDROCHLORIDE is used as a GABAa agonist for its hypnotic properties, helping in the treatment of sleep disorders and other related conditions. Its agonistic action on GABA-A receptors promotes relaxation and sedation, making it a valuable compound in the development of medications for insomnia and other sleep-related issues.
Used in Neurological Research:
In addition to its pharmaceutical applications, THIP HYDROCHLORIDE is also used as a GABAc antagonist in neurological research. This dual functionality allows scientists to study the effects of GABA-A and GABA-c receptors separately, leading to a better understanding of their roles in the central nervous system and the development of targeted therapies for neurological disorders.
Biological Activity
Systemically active GABA A receptor agonist and GABA C receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.
References
1) Meera et al. (2011), Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors; J. Neurophysiol., 106 2057
Check Digit Verification of cas no
The CAS Registry Mumber 64603-91-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,6,0 and 3 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 64603-91:
(7*6)+(6*4)+(5*6)+(4*0)+(3*3)+(2*9)+(1*1)=124
124 % 10 = 4
So 64603-91-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2O2.ClH/c9-6-4-1-2-7-3-5(4)10-8-6;/h7H,1-3H2,(H,8,9);1H
64603-91-4Relevant articles and documents
GABOXADOL FORMS, COMPOSITIONS THEREOF, AND RELATED METHODS
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Page/Page column 27, (2008/06/13)
The invention provides novel gaboxadol forms. These forms include salts, hydrates, solvates, and polymorphs of gaboxadol. The invention also provides novel compositions comprising these novel soluble forms and a suitable carrier. The invention also provides related methods of treatment. Compositions and methods of the invention of the invention have a number of uses, including the treatment or prevention of sleep disorders.
Heterocyclic compounds
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, (2008/06/13)
The compound Ia STR1 has been shown to possess GABA-related activity. The invention relates to Ia and derivatives thereof, covered by the formula STR2 in which R" is hydrogen, acetyl or a group of the general formula STR3 in which R5 is C1-8 alkyl; phenyl; phenyl substituted in the 4-position with halogen, lower alkoxy, or lower alkyl; or phenylalkyl in which the phenyl group may be substituted in the 4-position with halogen, lower alkoxy, or lower alkyl; and salts thereof. Novel intermediates for preparing I are STR4 in which Alk is a lower alkyl group and Z is hydrogen or an amino-protecting group; STR5 wherein Z is hydrogen or an amino-protecting group, T is a group convertible, by hydrolysis, into an oxy group, and Q is a leaving group which, on reaction with hydroxylamine, forms a hydroxamic acid group; STR6 wherein Z and T are as defined above; STR7 wherein Z is as defined above, and W is hydrogen or a group removable to yield the free hydroxy group, with the proviso that at least one of Z and W is different from hydrogen.
