647010-78-4Relevant articles and documents
The design of 8,8-dimethyl[1,6]naphthyridines as potential anticonvulsant agents
Austin, Nigel E.,Hadley, Michael S.,Harling, John D.,Harrington, Frank P.,Macdonald, Gregor J.,Mitchell, Darren J.,Riley, Graham J.,Stean, Tania O.,Stemp, Geoffrey,Stratton, Sharon C.,Thompson, Mervyn,Upton, Neil
, p. 1627 - 1629 (2007/10/03)
Starting from a series of 7-linked tetrahydroisoquinoline derivatives, as exemplified by SB-270664, a new series of 8,8-dimethylnaphthyridine compounds has been identified. SAR studies around these attractive leads have provided compounds such as 12 which display excellent anticonvulsant activity and an encouraging pharmacokinetic profile in vivo.
