6472-91-9

Basic information

• Product Name: CHRYSAMINE G
• Synonyms: CG;CHRYSAMINE;CHRYSAMINE G;CHRYSAMINE G DISODIUM SALT;CI NO 22250;4,4'-BIS-(3-CARBOXY-4-HYDROXYPHENYLAZO)BIPHENYL;4,4'-BIS(3-CARBOXY-4-HYDROXYPHENYLAZO)BIPHENYL DISODIUM SALT;5,5'-[[1,1'-BIPHENYL]-4,4'-DIYLBIS(AZO)BIS]2-HYDROXYBENZOIC ACID
• CAS NO: 6472-91-9
• Molecular Formula: C₂₆H₁₆N₄O₆*2Na
• Molecular Weight: 526.41
• Mol File: 6472-91-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 711.3°C at 760 mmHg
• Flash Point: 384°C
• Appearance: orange/solid
• Vapor Pressure: 3.1E-21mmHg at 25°C
• Storage Temp.: −20°C
• Solubility: DMSO: ~4 mg/mL
• Stability: Light Sensitive
• CAS DataBase Reference: CHRYSAMINE G(CAS DataBase Reference)
• NIST Chemistry Reference: CHRYSAMINE G(6472-91-9)
• EPA Substance Registry System: CHRYSAMINE G(6472-91-9)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 6472-91-9(Hazardous Substances Data)

Usage

Uses

Chrysamine G is a lipophilic derivative of Congo red and a βamyloid inhibitor.

Preparation

3-Acetylamino-N,N-diethylaniline double nitriding, and 2-Hydroxybenzoic acid (2 Moore) coupled.

Biochem/physiol Actions

New probe for ?-amyloid aggregates.

Properties and Applications

dark yellow. Soluble in water for lemon yellow, slightly soluble in alcohol. The strong sulfuric acid for quality of red, yellow for shallow diluted olives. The dye solution to join strong hydrochloric acid for yellow light olive; Add thick sodium hydroxide solution into orange (3-Acetylamino-N,N-diethylaniline type). Used for cellulose fiber, wool, silk dyeing, cellulose fiber fabric printing, discharge sex is good, levelness general. Standard Acid Resistance Alkali Resistance Light Fastness Soaping Water Fading Stain Fading Stain ISO 2-3 2 4 1-2 2-3

Standard

Acid Resistance

Fading

Stain

ISO

2-3

InChI:InChI=1/C26H18N4O6.2Na/c31-23-11-9-19(13-21(23)25(33)34)29-27-17-5-1-15(2-6-17)16-3-7-18(8-4-16)28-30-20-10-12-24(32)22(14-20)26(35)36;;/h1-14,27-28H,(H,33,34)(H,35,36);;/q;2*+1/p-2/b29-19-,30-20-;;

Upstream product

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Relevant articles and documents

Synthesis and evaluation of analogues of congo red as potential compounds against transmissible spongiform encephalopathies

The synthesis of analogues of the amyloid stain Congo red (1) as potential compounds against transmissible spongiform encephalopathies (TSEs) is reported. Using the direct method, aniline (2) or diamines such as 4,4′-diaminodiphenylsulfone (dapsone, 9), 3,3′-diaminodiphenylsulfone (10), benzidine (11), 3,3′-dimethoxybenzidine (12) or 3,3′-dichlorobenzidine (13) were diazotised to afford the corresponding diazonium salts, which without isolation, were directly used for coupling with a range of aromatic sulfonic or carboxylic acids to provide the corresponding truncated dyes analogues of Congo red, 4, 6, 8, and the symmetrical bis azoic dyes 14-19, 21-22, 24 and 26-29 as their sodium salts. Compounds were assayed in a cellular model of scrapie, a sheep TSE. Some of the compounds were shown to have similar activity to the lead compound Congo red. Molecular modelling was carried out to investigate potential structure-activity relationships (SARs) relating to the size and shape of Congo Red analogues. Within the range of compounds tested no discernible SARs were found.