64724-23-8

Basic information

• Product Name: 2-AMINO-5-CHLORO-3-IODOBENZOIC ACID
• Synonyms: 2-AMINO-5-CHLORO-3-IODOBENZOIC ACID
• CAS NO: 64724-23-8
• Molecular Formula: C₇H₅ClINO₂
• Molecular Weight: 297.48
• Product Categories: Acids & Esters;Anilines, Amides & Amines;Chlorine Compounds;Iodine Compounds
• Mol File: 64724-23-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 246-247 °C
• Boiling Point: 390.6±42.0 °C(Predicted)
• Appearance: /
• Density: 2.151±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.22±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-CHLORO-3-IODOBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-CHLORO-3-IODOBENZOIC ACID(64724-23-8)
• EPA Substance Registry System: 2-AMINO-5-CHLORO-3-IODOBENZOIC ACID(64724-23-8)

Safety Data

• Hazardous Substances Data: 64724-23-8(Hazardous Substances Data)

Usage

General Description

2-Amino-5-chloro-3-iodobenzoic acid is a chemical compound with the molecular formula C7H5ClINO2. It is a derivative of benzoic acid and contains both chlorine and iodine atoms. 2-AMINO-5-CHLORO-3-IODOBENZOIC ACID is commonly used in the synthesis of pharmaceuticals and as a building block for organic synthesis. Its structure and reactivity make it a versatile intermediate for creating a variety of organic compounds with potential applications in the pharmaceutical and chemical industries.

Upstream product

• 635-21-2 5-chloroanthranilic acid 
• 289039-84-5 methyl 2-amino-5-chloro-3-iodobenzoate 

Relevant articles and documents

Screening for covalent inhibitors using DNA-display of small molecule libraries functionalized with cysteine reactive moieties

DNA-encoded chemical libraries are increasingly used to identify leads for drug discovery or chemical biology. Despite the resurging interest in covalent inhibitors, libraries are typically designed with synthon filtered out for reactive functionalities that can engage a target through covalent interactions. Herein, we report the synthesis of two libraries containing Michael acceptors to identify cysteine reactive ligands. We developed a simple procedure to discriminate between covalent and high affinity non-covalent inhibitors using DNA display of the library in a microarray format. The methodology was validated with known covalent and high affinity non-covalent kinase inhibitors. Screening of the library revealed novel covalent inhibitors for MEK2 and ERBB2.