6479-18-1Relevant articles and documents
Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones
Ding, Ling,Liu, Yuxiu,Niu, Kaikai,Wang, Qingmin
supporting information, (2022/01/24)
Herein, we report a practical electro-reductive protocol for the direct C–H cyanoalkylation of quinoxalin-2(1H)-ones via iminyl radical-mediated ring opening. These mild reactions proceed under metal-, reductant-, and reagent-free conditions to provide synthetically useful cyanoalkylated quinoxalin-2(1H)-ones.
Application of biomass-supported copper-catalyzed three-component reaction in preparation of fluorine-containing drugs
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Paragraph 0047-0049, (2021/09/29)
The invention relates to an application of a biomass-supported copper-catalyzed three-component reaction in preparation of a fluorine-containing drug. The indole and its derivatives and are synthesized 3 - (2 - (trifluoromethyl) - indo -3 -yl) quinoxaline -2 - ketone derivatives by one-pot synthesis by three-component one-pot method. To the invention, the heterogeneous biological substance carried copper catalyst is adopted to catalyze the reaction, and the problems that a traditional homogeneous catalyst cannot be recovered, metal residues are left and the like are solved. 3 - (2 - (Trifluoromethyl) - indo -3 -yl) quinoxaline -2 - ketone compounds with different substituents are expanded, and the biomass supported copper catalyst can be cyclically and catalytically reacted.
N, N, N', N'-Tetramethylethylenediamine-Enabled Photoredox-Catalyzed C-H Methylation of N-Heteroarenes
Liu, Fang,Ye, Zhi-Peng,Hu, Yuan-Zhuo,Gao, Jie,Zheng, Lan,Chen, Kai,Xiang, Hao-Yue,Chen, Xiao-Qing,Yang, Hua
, p. 11905 - 11914 (2021/08/24)
Aiming at the valuable methylation process, readily available and inexpensive N,N,N′,N′-tetramethylethylenediamine (TMEDA) was first identified as a new methyl source in photoredox-catalyzed transformation in this work. By virtue of this simple methylating reagent, a facile and practical protocol for the direct C-H methylation of N-heteroarenes was developed, featuring mild reaction conditions, broad substrate scope, and scalability. Mechanistic studies disclosed that a sequential photoredox, base-assisted proton shift, fragmentation, and tautomerization process was essentially involved.