648449-76-7

Basic information

• Product Name: AS 604850
• Synonyms: AS 604850;PI3Kγ inhibitor, 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione;5-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylene]thiazolidine-2,4-dione;PI 3-Kinase Inhibitor (AS604850) B-0302;(Z)-5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione;5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione;PI 3-Kγ Inhibitor II
• CAS NO: 648449-76-7
• Molecular Formula: C11H5F2NO4S
• Molecular Weight: 285.225
• Product Categories: Inhibitors;Akt;mTOR;PI3K
• Mol File: 648449-76-7.mol
• Article Data: 1

Chemical Properties

• Appearance: off-white/
• Density: 1.71
• Storage Temp.: 2-8°C
• Solubility: DMSO: >10mg/mL
• PKA: 7.07±0.20(Predicted)
• CAS DataBase Reference: AS 604850(CAS DataBase Reference)
• NIST Chemistry Reference: AS 604850(648449-76-7)
• EPA Substance Registry System: AS 604850(648449-76-7)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 648449-76-7(Hazardous Substances Data)

Usage

Description

AS 604850 is a selective and ATP-competitive phosphoinositide 3-kinase gamma (PI3Kγ) inhibitor. It is a class 1B PI3K inhibitor that specifically targets the p110 catalytic subunit of PI3Kγ, which is involved in the phosphorylation of PI to produce second messengers. AS 604850 has demonstrated the ability to inhibit MCP-1-mediated monocyte chemotaxis and reduce RANTES-induced peritoneal neutrophil recruitment.

Uses

Used in Pharmaceutical Industry:
AS 604850 is used as a PI3Kγ inhibitor for targeting the PI3Kγ enzyme, which plays a crucial role in various cellular processes. Its selective inhibition can potentially be utilized in the development of therapeutic strategies for conditions involving the dysregulation of PI3Kγ signaling pathways.
Used in Immunology Research:
AS 604850 is used as a research tool for studying the role of PI3Kγ in immune cell function, particularly in leukocyte chemotaxis. Its ability to inhibit MCP-1-mediated monocyte chemotaxis and RANTES-induced neutrophil recruitment makes it a valuable compound for understanding the molecular mechanisms underlying immune cell migration and inflammation.
Used in Cancer Research:
AS 604850 is used as a potential therapeutic agent in cancer research, as the PI3Kγ pathway is often dysregulated in various types of cancer. The selective inhibition of PI3Kγ by AS 604850 may help in the development of targeted cancer therapies, particularly for those cancers where PI3Kγ plays a significant role in tumor progression and immune evasion.

references

1. camps m, rückle t, ji h et al. blockade of pi3k-gamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. nat med. 2005 sep;11(9):936-43.2. hohenester s, gates a, wimmer r et al. phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. j hepatol. 2010 nov;53(5):918-26.

Relevant articles and documents

AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES

The present invention is related to azolidinedione-vinyl fused-benzene derivatives of formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, graft rejection or lung injuries. Formula (I), wherein A, X, Y, Z, R1 , R2 and n are as described in the description.