64945-22-8Relevant articles and documents
Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 2: (3-substituted-5-halo-2-pyridinyl)guanidines
Barber, Christopher G.,Dickinson, Roger P.
, p. 185 - 187 (2007/10/03)
Based on previous modeling predictions, a series of (3-substituted-5-chloro-2-pyridinyl)guanidines have been designed with good potency and selectivity for urokinase-type plasminogen activator (uPA). Compound 36 has a Ki of 0.17 μM and greater than 300-fold selectivity with respect to tPA and plasmin.