64967-39-1

Basic information

• Product Name: N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine
• Synonyms: N-[(2S,3R)-3-AMINO-2-HYDROXY-1-OXO-4-PHENYLBUTYL]-L-LEUCINE;N-((2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-LEU;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-LEU-OH;[(2S, 3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE;Glycine, N-3-(2-furanyl)-1-oxo-2-propenyl-L-phenylalanylglycyl-;2-furanacryloyl-phenylalanyl-glycyl-glycine
• CAS NO: 64967-39-1
• Molecular Formula: C₂₀H₂₁N₃O₆
• Molecular Weight: 399.4
• EINECS: 261-529-2
• Product Categories: Enzyme substrates
• Mol File: 64967-39-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 245 °C (dec.)(lit.)
• Boiling Point: 842.3 °C at 760 mmHg
• Flash Point: 463.2 °C
• Appearance: OFF-WHITE TO LIGHT TAN POWDER
• Density: 1.321 g/cm³
• Vapor Pressure: 3.9E-30mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: −20°C
• Solubility: NH4OH 1 M: 50 mg/mL, clear to slightly turbid, yellow
• PKA: 3.32±0.10(Predicted)
• CAS DataBase Reference: N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine(64967-39-1)
• EPA Substance Registry System: N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine(64967-39-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: OH2915000
• Hazardous Substances Data: 64967-39-1(Hazardous Substances Data)

Usage

Description

N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine, also known as N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly, is a white powder chemical compound that serves as a substrate for the continuous spectrophotometric assay of angiotensin-converting enzyme (ACE). It is specifically designed to act as a substrate for ACE, allowing for the measurement of the enzyme's activity and inhibition.

Uses

1. Used in Pharmaceutical Research:
N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine is used as a substrate for the continuous spectrophotometric assay of ACE. This application is crucial in pharmaceutical research for the development of new drugs targeting ACE, which plays a significant role in regulating blood pressure and is a therapeutic target for hypertension and other cardiovascular diseases.
2. Used in Kinetic Spectrophotometric Assay:
N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly has been utilized for the kinetic spectrophotometric assay of ACE inhibitory activity. This application is essential in determining the effectiveness of potential ACE inhibitors, which can be used in the treatment of hypertension and other related conditions.
3. Used in Drug Development:
In the drug development industry, N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine is used as a benchmark for evaluating the potency and selectivity of new compounds designed to inhibit ACE. This helps researchers identify promising drug candidates that can potentially be used in the treatment of hypertension and other cardiovascular diseases.

InChI:InChI=1/C20H21N3O6/c24-17(9-8-15-7-4-10-29-15)23-16(11-14-5-2-1-3-6-14)20(28)22-12-18(25)21-13-19(26)27/h1-10,16H,11-13H2,(H,21,25)(H,22,28)(H,23,24)(H,26,27)/b9-8+/t16-/m0/s1

Upstream product

• 103972-53-8 N^α-furylacryloylphenylalanylglycylglycine ethyl ester 
• 2440-94-0 quinolin-8-yl ester of N-benzyloxycarbonyl-L-phenylalanine 
• 67998-15-6 (E)-3-(furan-2-yl)acrylic anhydride 
• 4526-84-5 N^α-benzyloxycarbonylphenylalanylglycylglycine ethyl ester 
• 539-47-9 3-(fur-2-yl)crotonic acid 

Relevant articles and documents

SYNTHESIS OF N-FURYLACRYLOYL DERIVATIVES OF AMINO ACIDS AND PEPTIDES, CHROMOGENIC SUBSTRATES OF PROTEOLYTIC ENZYMES, USING FURYLACRYLIC ACID ANHYDRIDE

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