649755-75-9

Basic information

• Product Name: (R)-3-[(2R,3S,4S)-2,4-dimethyl-3,5-bis(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one
• Synonyms: (R)-3-[(2R,3S,4S)-2,4-dimethyl-3,5-bis(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one
• CAS NO: 649755-75-9
• Molecular Weight: 654.05
• Mol File: 649755-75-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-3-[(2R,3S,4S)-2,4-dimethyl-3,5-bis(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-[(2R,3S,4S)-2,4-dimethyl-3,5-bis(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one(649755-75-9)
• EPA Substance Registry System: (R)-3-[(2R,3S,4S)-2,4-dimethyl-3,5-bis(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one(649755-75-9)

Safety Data

• Hazardous Substances Data: 649755-75-9(Hazardous Substances Data)

Upstream product

• 443761-69-1 (R)-3-[(2R,3S,4S)-3,5-dihydroxy-2,4-dimethylpentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 994-30-9 triethylsilyl chloride 

Downstream Products

• 649755-77-1 (3R,4S,5S)-3,5-dimethyl-4-[(triethylsilanyl)oxy]tetrahydropyran-2-one 
• 191090-32-1 (R)-4-(1-methylethyl)-5,5-diphenyl-1,3-oxazolidin-2-one 
• 649755-76-0 (R)-3-[(2R,3S,4S)-5-hydroxy-2,4-dimethyl-3-(triethylsilanyloxy)pentanoyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one 

Relevant articles and documents

A practical building block for the synthesis of discodermolide

A new highly diastereoselective and practical route to the lactone 6a which is used as a key building block for the total synthesis of the microtubule-stabilizing anticancer agent discodermolide is reported. This exploits the chiral auxiliary (4R)-4-isopr